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valuk

铁虫 (初入文坛)

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虫号: 279541
注册: 2006-09-16
性别: GG
专业: Chemical Engineering

[交流] 权威经典 Bioreaction Engineering principles (Second Edition) 附珍贵资料

这本书堪称生物工程技术领域的权威著作。虽与生物有关，但内容偏重工程方
面，是生物技术与化学工程的交叉领域。后面附有本书印刷错误的更正，此资
料是直接从作者处获得的第一手资料。弥足珍贵，愿与各位分享。此处虽提供
电子版下载，但如果各位发现这本书很好还请购买正版书籍，尊重作者劳动。

这本书我实在不知道该发在哪个版才好，生化似乎沾边，但是这个更多的却是
工程方面的东西。只好先发在这个版了。版主觉得有什么更好的选择再转到其
他版吧。

Bioreaction Engineering Principles(Second Edition)

Biotechnology is a rapidly moving field, which builds on the competence and interplay of many different disciplines; biochemistry, microbiology, molecular biology and chemical engineering. The quantitative treatment of biological processes is today a prerequisite for both the design of new bioprocesses and the analysis of cellular function.The present text is an extensively revised edition of the textbook first published in 1994. The quantitative treatment of bioprocesses is a central theme in this book. The book has been restructured to make it more easily accessible to the reader, the material has been updated and several new topics have been added in the text.The focus is on the bioreactor and the processes that occur in the reactor, i.e. the coupling between the reactions occurring in the cell and its environment. The microbial cellular metabolism is the starting point in the treatment. Tools for the quantitative analysis of cellular functions - macroscopic mass balancing, thermodynamics of microbial processes, metabolic network analysis and kinetic modelling - are gradually introduced. After analysis of the cellular reactor, the interaction between the cell and its environment is treated in chapters concerning mass transfer and design of bioprocesses. Finally, the complex subject of scale-up is presented.The book combines, in a rather unique way, a quantitative treatment of physiology at the cellular level with a treatment of the bioreactor and interaction between the cellular reactor and the bioreactor. Many examples and problems are used to illustrate important concepts in the text.

The following part is the misprints I received from the author. It is really rare and valuable. Please do not misuse.

´This is a list of misprints in “Bioreaction Engineering Principles”, 2. Ed (2002).

The list has last been updated on  November 1, 2005. It will be up-dated continuously when we find more misprints
Jens Nielsen, John Villadsen and Gunnar Lidén.

p. 36 Figure 2.8 : A number of last letters has disappeared (Cephalosporin, Cephamycin, biosynthesis.)

p.49 line under Eq(3.1): Correct “space-time” to “space-velocity”

p.61 Eq(3.26): The coefficient on NH3 should be 1/5.

p.62 : The degree of reduction of urea (NH2-CO-NH2) should be 0.

p.69  line13b : slope is 30.0 → slope is 33…Yxc = 25.17*0.033 = 0.82…

p.55, Table 3.1: The formula weight of RNA is 26.0 g (C-mole)-1.

p.88 line 2b . ..25μM. At 30oC and πo = 1 atm so* = 1.16 mM.

p.89 line 15b… question 6→question a, and (question 4)→(question d).

p.90 line 6: Correct “The yield Ysx is that calculated above” to “The yields Ysx and Ysn are the same as in question b.”

p.91 Insert a minus sign in front of CH2O(HAc), and thye→the.

p.110 Figure 4.1 has been mishandled. 1. Insert Fumarate as the product from Succinate.  2. The input is NADH (and not NAD). 3. The enzyme is ATPase, and it converts ADP to ATP when H+ is transported back to the mitochondria. 4. The arrow pointing to O2 is misleading-the figure text tells the correct story.

p.127 line 1  ms → mATP

p.124 : One line is missing after Eq(5.2): “where TATP is a column vector containing all the stoichiometric coefficients for ATP, i.e, it is the…”

p.138  line 4: Eqs(7) and (8)→ Eqs(6) and (7)

p.139 Eq.(4). The upper equation should read : 2(-ro) = 2 v2 + 0.1 v1.

p.143 Figure at bottom of the page: NADH is converted to NAD.

p.147  line 10b : correct rac to ra (twice)

p.161: (see also Note 5.4)→(see also Note 5.5)

p.171 The section numbering should be 5.4.3

p.185  The answers quoted are valid if Ys,ATP = 1/3 in v3

p.186 Reference to Christiansen, T, and Nielsen, J: Bioproc.Biosystems.Eng.24, 329-339
         Reference to van Rolleghem and Heijnen, Biotechnol.Bioeng.(1998), 58, 133-138.
p.193 Delete the footnote (the story may be apocryphal)

p.200 Figure text: Correct competitive to non-competitive.

p.308-309. There are several errors in the text of Problem 7.3. 1. Eq.(1): The KS in the denominator should be K2 . 2. Text below eq.(1): K1= K11K12K13K14 (the first index is erroneously printed as a “4”). 3. Just below the definition of K1: Correct the last ≈ to <<. 4. Above eq.1: Correct K44 to K2 (i.e. K41=K42=K43=K2).

p.358 line 1 from top: X = x/(sf Ysxtrue). Also Figure 9.3 D is wrong. One should depict
Ysxtruesf S/(S + b(S + a))/qx against S in order to obtain an ordinate that is μ-1(1-S)-1. But now Figure 9.3 D becomes identical to Figure 9.3 A. Consequently the same τmin is obtained, but the biomass yield is of course lower than for no maintenance.

p.370 last line : (24.6/30) ; change to (30/24.6). The answer 0.02114 is correct.

p.382 Eq.(9.88 b): Add a term  Ysx sf on the right hand side of the equation.

p.391 Eq.(9.105), inside the √  : Change sign in front of D to a minus sign.

p.409 line 10b: V→V1

p.414 line 9 from top: Change to βs = Ysxtrue ms.

p.429 formula (10.11).  The exponent on the last factor is 1/3

p.448 Table 10.8: The solubility at 40oC is 1.03 mmoles L-1

p.452 Eq.(12): Change c*o(DOT – 1) to (co –c*o).

p. 465 Eq (10.52) incorrect. Should read

p.472  line 5: μmax→ ro,max

p.584  Left hand expression of Eq(2): The denominator should read s∞ - so.

p.510  One line in the table is wrong (reciprocal numbers were erroneously inserted)
Hence, correct the tc line to : 1    2.94    1       5    25.

p. 513 Eq(1): The stoichiometric coefficient of biomass should be 0. 456.

p. 514. Problem 11.1., third sentence. Should be:
"Suppose now instead that the impeller diameter of the 1 m3 reactor is chosen.."

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[ Last edited by valuk on 2006-9-17 at 21:40 ]

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