Furthermore, in situ hybridization analysis has revealed that MT1-MMP mRNA is expressed by fibroblasts surrounding tumour cells, indicating that increased expression of MT1-MMP by fibroblasts can contribute to tumour progression as a result of MMP-2 activation in the tumour cells. Considering the present in vitro and in vivo results,
increased MMP-2 activity coupled with TIMP-2 and MT1-MMP expression by keloid fibroblasts can also contribute to invasion of keloid fibroblasts into surrounding non-keloid regions through ECM degradation, as similarly demonstrated in various tumours.
注：MMP-基质金属蛋白酶 。 TIMP-基质金属蛋白酶抑制剂 ECM-细胞外基质
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