24小时热门版块排行榜

返回列表

本帖产生 1 个 MicEPI ，点击这里进行查看

当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖

wangyun0917

铜虫 (小有名气)

应助: 1 (幼儿园)
金币: 89.6
帖子: 202
在线: 53.7小时
虫号: 1184184

[交流] 【求助/交流】筛菌方法目前的研究进展

请问筛菌方法目前的研究进展，有哪位高人能推荐给我两三篇介绍这方面的外文文献吗？？？我的课题刚开始，马上就要向老板汇报筛菌方法了。。。

回复此楼

» 猜你喜欢

» 抢金币啦！回帖就可以得到:

查看全部散金贴

1楼 2011-03-31 10:50:38

已阅回复此楼关注TA 给TA发消息送TA红花 TA的回帖

mingzhu392

木虫 (著名写手)

应助: 3 (幼儿园)
金币: 6809.4
帖子: 1330
在线: 2622.5小时
虫号: 1082505

★
小木虫(金币+0.5):给个红包，谢谢回帖

来学习啦。嘿嘿。谢谢分享

回复此楼

45楼2011-06-08 16:48:11

已阅回复此楼关注TA 给TA发消息送TA红花 TA的回帖

查看全部 47 个回答

ljzm

木虫 (小有名气)

MicEPI: 1
应助: 1 (幼儿园)
金币: 1853
帖子: 117
在线: 78.3小时
虫号: 1104464

★ ★ ★ ★ ★ ★
rainwander(金币+3): 鼓励分享~~~ 2011-03-31 20:07:14
scelab(金币+3): 追加奖励~~~ 2011-03-31 20:09:58
wangyun0917(金币+10): 真的非常感谢阁下，我是一个刚入门的，金币不多，还希望以后多多指教！！！ 2011-04-01 11:05:25
rainwander(EPI+1): 不错~ 2011-04-03 15:28:28

Abstract
Industrial strain improvement plays a central role in the commercial development of microbial fermentation processes. In recent years new procedures such as rational screening and genetic engineering have begun to make a significant contribution to this activity but mutagenesis and selection - so-called ‘random screening’ - is still a cost-effective procedure, and for reliable short-term strain development is frequently the method of choice. The current practice of strain improvement by mutagenesis and selection is a highly developed technique drawing on the latest advances from a wide range of scientific and technical disciplines. Mutagenic procedures can be optimized in terms of type of mutagen and dose, mutagen specificity effects can be taken into account and mutagenesis itself can be enhanced or directed in order to obtain the maximum frequency of desirable mutant types among the isolates to be screened. Screens can be designed to allow maximum expression of the desirable mutant types and the application of statistically-based screening procedures will maximize the probability of detecting them. Automated procedures can be developed using robotics and microprocessors to increase the numbers of isolates that can be processed through a screen per unit time. The relationship between screening and production conditions can be organized so as to minimize the probability of improved isolates selected by the screen failing to scale up.