| 查看: 672 | 回复: 1 | |||
[交流]
【讨论】Nanodiamonds Fight Cancer 已有1人参与
|
|
http://pubs.acs.org/cen/news/89/i11/8911notw3.html Faceted nanoparticles shaped somewhat like cut diamonds not only can deliver drugs to tumor cells but also can ensure that the small molecules stick around long enough to do some good, a research team has found (Sci. Trans. Med., DOI: 10.1126/scitranslmed.3001713). Chemotherapy often fails because cells protect themselves by pumping out foreign substances via transmembrane transporter proteins. As a result, physicians have to administer cancer therapeutics at high, and sometimes harmful, concentrations for them to be efficacious. Nanoparticles—materials that can’t as easily be kicked out of cells and can hold high concentrations of bound molecules—show promise as drug delivery vehicles. The 2- to 8-nm-diameter carbon-based nanodiamonds, in particular, “have unique electrostatic properties that promote potent binding of drugs” and are ideal for chemotherapy, says Dean Ho, the research team’s leader and a biomedical engineering professor at Northwestern University. By binding the cancer agent doxorubicin to nanodiamonds, Ho and his team demonstrated particle-mediated delivery of the drug to both liver and mammary gland tumor cells in mice. In both cases, seven days after injection, the drug-loaded nanodiamonds killed about three times as many tumor cells as doxorubicin alone. They also circulated in the blood of the mice 10 times as long as the unbound cancer agent. When treated with a high dose (200 µg) of doxorubicin, mice riddled with mammary gland tumors died after 15 days. But those treated with an equivalent dose of a nanodiamond-doxorubicin complex , which is thought to release the drug slowly over time, had a nearly 100% survival rate over the course of the eight-week study, and their tumors decreased in size by about 50%. “What is new and striking” about this work, says Fuyu Tamanoi, a biochemist at the University of California, Los Angeles, is that the nanodiamond-doxorubicin formulation blocks tumor growth in the mice with drug-resistant mammary gland tumors cells. “This suggests that nanodiamonds can overcome drug resistance,” he says. 我给作者 发了邮件，表示我的看法 I have some questions: 1 Nanodiamonds (carbon) is inert and hardly degradable in body. Would it cause some damage to patient ? 2 Will you consider apply some biodegradable material to combine with drug,such as PLA, PGA ? 没有得到教授回复，也许我的问题不值一提。 各位有空的话，可以发表点看法，十分感谢。 |
回复此楼» 猜你喜欢
胰岛素的实验室表达
已经有1人回复
-
胰岛素的实验室表达
已经有0人回复
-
药理学论文润色/翻译怎么收费?
已经有247人回复
-
胰岛素的实验室表达
已经有0人回复
-
求助电子版：晶型药物研发理论与应用
已经有0人回复
-
祈福面上能中
已经有141人回复
-
北京大学药学院诚招药物化学/有机化学方向博士后
已经有6人回复
-
2027药学博士申请
已经有1人回复
-
求Endnote官网关于《Avian Conservation and Ecology》杂志的.ens文件
已经有2人回复
2楼2011-03-21 23:29:54
20
投票:
