| 查看: 5030 | 回复: 80 | |||||||
| 【奖励】 本帖被评价67次，作者linyingjia增加金币 52.8 个 | |||||||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | |||||||
[资源]
【分享】肿瘤学中又一篇经典必读文章 Hallmarks of Cancer: The Next Generation
|
|||||||
|
做肿瘤的一定都知道Robert A. Weinberg，他在2000年发表在Cell上的《The hallmarks of cancer》现在的引用次数已经超过10000次，几乎做肿瘤的每一个人都会看这么一篇经典文章。在2011年3月4日，他又在Cell上继续发表了题为《Hallmarks of Cancer: The Next Generation》的文章，将肿瘤的六种武器扩充到十种武器。我觉得这又堪称是肿瘤学研究中经典与必读文章了。 Summary The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis. Underlying these hallmarks are genome instability, which generates the genetic diversity that expedites their acquisition, and inflammation, which fosters multiple hallmark functions. Conceptual progress in the last decade has added two emerging hallmarks of potential generality to this list—reprogramming of energy metabolism and evading immune destruction. In addition to cancer cells, tumors exhibit another dimension of complexity: they contain a repertoire of recruited, ostensibly normal cells that contribute to the acquisition of hallmark traits by creating the “tumor microenvironment.” Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer. http://www.cell.com/abstract/S0092-8674(11)00127-9 [ Last edited by linyingjia on 2011-3-6 at 08:21 ] |
回复此楼» 收录本帖的淘帖专辑推荐
 生物-学习资源 | 知识 | 科研 | 生物资料 |
| 细胞 |
» 猜你喜欢
导师想让我从独立一作变成了共一第一
已经有9人回复
-
博士读完未来一定会好吗
已经有23人回复
-
到新单位后，换了新的研究方向，没有团队，持续积累2区以上论文，能申请到面上吗
已经有11人回复
-
读博
已经有4人回复
-
JMPT 期刊投稿流程
已经有4人回复
-
心脉受损
已经有5人回复
-
Springer期刊投稿求助
已经有4人回复
-
小论文投稿
已经有3人回复
-
申请2026年博士
已经有6人回复
» 本主题相关价值贴推荐，对您同样有帮助:
我看CIK肿瘤生物治疗
已经有15人回复- Hallmarks of Cancer中文版
已经有10人回复
- 【求助/交流】cancer 和 tumor 有区别吗
已经有9人回复
14楼2011-05-16 18:36:43
3楼2011-03-06 10:35:12
6楼2011-05-07 14:51:42
9楼2011-05-07 19:21:56
简单回复
yuane4楼
2011-05-07 10:18
回复
五星好评 顶一下，感谢分享！
2011-05-07 19:19
回复
三星好评 顶一下，感谢分享！
2011-05-07 19:20
回复
顶一下，感谢分享！
zhru312楼
2011-05-15 01:30
回复
五星好评 顶一下，感谢分享！
zhru313楼
2011-05-15 01:34
回复
顶一下，感谢分享！