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panl234

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[交流] 【求助/交流】c-jun的全称是什么? 已有3人参与

谁知道c-jun的全称是什么?
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xp198766

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小木虫职业打酱油滴~~!

google试试
2楼2011-01-10 18:03:35
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brightfuture01

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文献杰出贡献

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小木虫(金币+0.5):给个红包,谢谢回帖交流
amisking(金币+3):good! 2011-01-10 22:02:29
很奇怪的命名啊,我前几天看文献看到这个还以为是中国人最先发现的一个什么蛋白。

wiki了一下:

http://en.wikipedia.org/wiki/C-jun

c-Jun is the name of a gene and protein that, in combination with c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the c-jun gene. It is activated through double phosphorylation by the JNK pathway but has also a phosphorylation-independent function. c-Jun knockout is lethal, but transgenic animals with a mutated c-Jun that cannot be phosphorylated (termed c-JunAA) can survive.

This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein that is highly similar to the viral protein, and that interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies.[1]
The world is a fine place and worth fighting for. I agree with the second part.
3楼2011-01-10 18:09:05
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503230625

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百度或谷歌搜一下
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4楼2011-01-10 19:42:44
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