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xu_0501(金币+200, 翻译EPI+1):您翻译得很好啊，表述很简洁，感谢，感谢! 2010-11-13 15:03:27
楼上的有机器翻译的嫌疑，很多句子都读不通，请楼主仔细看看哦
下面是我自己的翻译
第一段：
With P. infestans as the experimental objects, the SAR analysis was carried on the EC50 results of antifungal activity test showed in table 5.3. The results showed: (1) the EC50 values of 16 2-methylsulfonyl-5-substituent-thiadiazole derivatives on P. infestans were between 10.05 ug/mL and 59.52 ug/mL while that of hymexazol was 26.49 ug/mL. The EC50 values of compound Ⅷ2, Ⅷ3, Ⅷ4, Ⅷ14, Ⅷ19, Ⅷ21 and Ⅷ28 were 11.53 ug/mL, 1.64 ug/mL, 14.93ug/mL, 11.32 ug/mL, 14.73 ug/mL, 10.05 ug/mL and 10.44 ug/mL, respectively, which were below 15 ug/mL. EC50 of the lowest activity of comound Ⅷ22 on P. infestans was 59.52 ug/mL. (2) Compired the same substituents on the aryl, monosubstituents had better activity than polysubstituents. For example, EC50 of compound Ⅷ18 (R=2,3-2 Cl) on P. infestans was 21.51 ug/mL, and that of compound Ⅷ28(R=3-Cl) on P. infestans was 10.44 ug/mL; EC50 of compound Ⅷ19(R=2-F) on P. infestans was 14.73 ug/mL, and that of compound Ⅷ22 (R=2,6-2F) on P. infestans was 59.52 ug/mL. (3) when there were 2,6 disubstituents by electron withdrawing group, the compound had bad activity. For example, EC50 of compound Ⅷ22 (R=2,6-2F) on P. infestans was 59.52 ug/mL and that of compound Ⅷ26 (R=2,6-Cl) on P. infestans was 42.93 ug/mL. (4) Compired with the same substituents on the aryl, the p-substituted compund had higher activity than the compounds substituted at other sites. For example, EC50 of compound Ⅷ16 (R=4-Br) on P. infestans (28.52 ug/mL) was higher than that of compound Ⅷ29 (R=2-Br) (49.64 ug/mL).
第二段：
With S. sclerotiorum as the experimental objects, the SAR analysis was carried on the EC50 results of antifungal activity test showed in table 5.3. The results showed: (1) 16 2-methylsulfonyl-5-substituent-thiadiazole derivatives on S. sclerotiorum had good antifungal activity and their EC50 values were between 1.87 ug/mL and 17.02 ug/mL while that of hymexazol was 7.76 ug/mL. The EC50 values of compound Ⅷ3, Ⅷ14, Ⅷ21 and Ⅷ28 were 1.87 ug/mL, 6.11 ug/mL, 6.97 ug/mL and 4.50 ug/mL, respectively, which were below 7 ug/mL. EC50 of the lowest activity of comound Ⅷ18 was 15.08 ug/mL. (2) At the same substituted position of the aryl, the stronger the electron withdrawing ability of substituted group , the higher the activity of the compound. For example, the activity of compound Ⅷ19 (R=2-F) on S. sclerotiorum (EC50=8.49 ug/mL) was higher than that of compound Ⅷ29(R=2-Br) (EC50=14.78 ug/mL) (3) Compired with the same substituents on the aryl, monosubstituents had higher activity than polysubstituents. For example, EC50 of compound Ⅷ4 (R=2-Cl) on S. sclerotiorum was 8.57 ug/mL, while EC50 values of compound Ⅷ18 (R=2,3-2Cl) and Ⅷ23 (R=2,6-2Cl) were 15.08 ug/mL and 17.20 ug/mL, respectively, and both of them had much lower activity than monosubstituents. (4) Compired with the same substituents at different positions of the aryl, the p-substituted compund had higher activity than the compounds substituted at other sites. For example, the activity of compound Ⅷ16 (R=4-Br) on S. sclerotiorum (EC50=9.82 ug/mL) was higher than that of compound Ⅷ29 (R=2-Br) (EC50=14.78 ug/mL).
第三段：
With F. oxysporum as the experimental objects, the SAR analysis was carried on the EC50 results of antifungal activity test showed in table 5.3. The results showed: (1) the EC50 values of 16 2-methylsulfonyl-5-substituent-thiadiazole derivatives on F. oxysporum were between 6.67 ug/mL and 85.41 ug/mL while that of hymexazol was 27.93 ug/mL. The EC50 values of compound Ⅷ3, Ⅷ14 and Ⅷ28 were 6.67 ug/mL, 8.52 ug/mL and 9.4 ug/mL, respectively, which were below 10 ug/mL. The EC50 of the lowest activity of compound Ⅷ23 on F. oxysporum was 85.41 ug/mL. (2) At the same substituted position of the aryl, the activity of the compounds with electron withdrawing group was higher than that of the compounds with electron donating group. For example, EC50 of compound Ⅷ5(R=3,4-2F) on F. oxysporum was 19.15 ug/mL while that of compound Ⅷ23 (R=2,6-2OCH3) was 61.66 ug/mL. (3) Compired with the same substituents on the aryl, monosubstituents had higher activity than polysubstituents. For example, EC50 of compound Ⅷ23 (R=2,6-2Cl) on F. oxysporum was 85.41 ug/mL while that of compound Ⅷ4 (R=2-Cl) on F. oxysporum was 30.48 ug/mL. (4) Compired with the same substituents at different positions of the aryl, the p-substituted compund had higher activity than the compounds substituted at other sites. For example, the activity of compound Ⅷ16 (R=4-Br) on F. oxysporum (EC50=21.48 ug/mL) was higher than that of compound Ⅷ29 (R=2-Br) (EC50=29.89 ug/mL).
第四段：
With B. cinerea as the experimental objects, the SAR analysis was carried on the EC50 results of antifungal activity test showed in table 5.3. The results showed: (1) the EC50 values of 16 2-methylsulfonyl-5-substituent-thiadiazole derivatives on B. cinerea were between 0.18 ug/mL and 21.00 ug/mL. The EC50 values of compound Ⅷ3, Ⅷ14, Ⅷ21 and Ⅷ24 were 0.18 ug/mL, 2.26 ug/mL, 1.99 ug/mL and 2.5 ug/mL, respectively, which were below 5 ug/mL. The EC50 of the compound Ⅷ29 on B. cinerea was 21 ug/mL, which was the highest one. (2) At the same substituted position of the aryl, the activity of the compounds with electron withdrawing group was higher than that of the compounds with electron donating group. For example, EC50 of compound Ⅷ5(R=3,4-2F) on B. cinerea was 2.51 ug/mL while that of compound Ⅷ2 (R=3,4-2OCH3) was 6.89 ug/mL. (3) With different type of substituted group at the same substituted position on the aryl, the activity of the compound with electron withdrawing group was higher than that of the compound with electron donating group. For example, EC50 of compound Ⅷ19(R=2-F) on B. cinerea was 5.21 ug/mL while that of compound Ⅷ29(R=2-Br) was 21 ug/mL at the same condition. (4) Compired with the same substituents on the aryl, monosubstituents had higher activity than polysubstituents. For example, EC50 of compound Ⅷ19 (R=2-F) on B. cinerea was 5.21 ug/mL while that of compound Ⅷ22 (R=2,6-2F) was 8.25 ug/mL; EC50 of compound Ⅷ4 (R=2-Cl) on B. cinerea was 7.23 ug/mL while that of compound Ⅷ23 (R=2,6-2Cl) was 8.03 ug/mL. (5) Compired with the same substituents on the aryl, the p-substituted compund had higher activity than the compounds substituted at other sites. For example, the activity of compound Ⅷ16 (R=4-Br) on B. cinerea (EC50=4.85 ug/mL) was higher than that of compound Ⅷ29 (R=2-Br) (EC50=29.89 ug/mL). |
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