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panyulian0

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A sol–gel imprinted with N-[N-[(1S)-1-carboxy-3-
phenylpropyl]-l-lysyl]-l-proline, lisinopril dihydrate, was
successfully synthesised which illustrated enhanced selectivity
by the MIP over a NIP. Specificity of the MIP for the
template over two of its listed related substances was also
achieved. It was noted that the quantity of lisinopril reloaded
onto the polymeric material was important in observing selectivity
for the template. Optimisation of loading illustrated
the binding capacity of the polymer. When the polymer was
saturated with template, selectivity was lost. A key factor in
optimising selectivity was found to be the solvent in which
the template was dissolved for rebinding. The loading solvent,
which gave best selectivity for lisinopril, was the porogen
used in the synthesis of the original polymeric material. It
was noted that a certain degree of cross-linker must be present
in order for the polymer to form and for optimum template
selectivity but at higher concentrations selectivity was lost.
For the functional monomers it was noted that the – interacting
monomer (PTMOS) was required in small quantities
to produce a selective medium. The smallest change in the
concentration of hydrogen bonding species (APTES) greatly
affected selectivity of the polymer. Above and below the optimum
ratio of 1.5, selectivity was lost and almost complete
retention of the template by both NIP and MIP was observed.
Reproducible responses were noted for both NIP and MIP
materials for the template over an 8-month-time-period. Further
optimisation of this polymeric system is envisaged in order
to reduce the observed non-specific binding of template
by the NIP.

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