| 查看: 5262 | 回复: 16 | ||||||
| 【奖励】 本帖被评价7次，作者qinfujun增加金币 5.6 个 | ||||||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | ||||||
[资源]
【资源分享】研究计划和归国计划，根据以往的一些虫友的改编 已有2人参与
|
||||||
|
Advisor’s information Name:****** Organization: Northwestern University Academic position: ****** Professor E-mail: ******@northwestern.edu TEL: ****** Address: ******, Chicago, IL 60611 Research plan Background:A number of key transcription factors, including the Androgen Receptor, the Polycomb group protein EZH2, and the TMPRSS2:ERG gene fusions, have been related to epigenetic changes and implicated in prostate cancer. As transcriptional regulation, for instance those by EZH2, eventually leads to inheritable epigenetic changes and thus altered chromatin status. Epigenetic mechanisms may be fundamental to tumorigenesis. Based on lab’s previous work, we hypothesized that in aggressive tumors altered transcriptional controls and chromatin states lead to de-differentiation and a stem cell like cellular status. In our study we will reveal the link between transcriptional control and epigenetic changes including histone methylation, DNA methylation and the regulation of miRNAs. Therefore the proposed work seeks to find the mechanisms between epigenetic regulation and prostate cancer. We plan to do the following projects: Project 1: Cell Culture and In Vitro Overexpression, Inhibition and Function Assays. From November 2010 to February 2011, I will conduct experiments on: cell lines culture, expression vector construct, RNA analysis by RT-PCR. Project 2: Protein Interaction Assay, ChIP-Seq Assays and Bioinformatics Analysis. From March 2011 to August 2011, I will perform the Assays on: Protein interaction between target genes, Chromatin immunoprecipitation using the histone methylation antibody and sequence the DNA fragments, Search the binding site sequence by Bioinformatics analysis. Project 3: Paper Writing and Publication From September 2011 to October 2011, I will write my research paper and submit it to a high influence factor journal. Return plan Epigenetic regulation, as one of the most fascinating research fields, has appeared in US & Europe since 2000’s. Now this discipline has emerged as a new research frontier and received more and more attention in the world. However, in China, epigenetics has only received little attention compared to overseas. In many universities and institutes, few people concentrate on epigenetic regulation. So plenty of researchers will be needed to work on this discipline in the near future. With good expertise in epigenetic research including histone methylation and DNA methylation acquired in National Key Laboratory of Crop Genetic Improvement (Huazhong Agricultural University) in past seven years and a deeper insight into epigenetic regulation that will be acquired in Northwestern University, I am full of confidence that after the completion of my post-doctoral research program, I will be able to find a suitable academic position in some university or institute in littoral of China or my home province. With good training in U.S and profound knowledge in epigenetics, I am confident of myself that I will be more competitive and have a much better chance in China. In addition, I will share my research experience abroad with future colleagues in China. [ Last edited by lywang2008 on 2010-12-7 at 06:24 ] |
回复此楼» 收录本帖的淘帖专辑推荐
 大慈大悲观世音 | 美国J签证经验 | 宝贵资料 | 花花要留学 |
» 猜你喜欢
268求调剂
已经有3人回复
-
302求调剂
已经有5人回复
-
311求调剂
已经有10人回复
-
被我言中：新模板不强调格式了，假专家开始管格式了
已经有4人回复
-
303求调剂
已经有5人回复
-
考研求调剂
已经有4人回复
-
085601专硕，总分342求调剂，地区不限
已经有4人回复
-
085601材料工程专硕求调剂
已经有5人回复
-
一志愿天津大学化学工艺专业（081702）315分求调剂
已经有6人回复
-
能源材料化学课题组招收硕士研究生8-10名
已经有6人回复
» 本主题相关价值贴推荐，对您同样有帮助:
- 求问如何写研究计划？请大家指点迷津~交流经验~
已经有14人回复
- 请教各位关于研究计划的一些问题？在线等。。。
已经有10人回复
- 怎样的研究计划才叫漂亮
已经有17人回复
- 英国纽卡斯尔大学 奖学金申请、研究计划问题！焦急求教！！
已经有14人回复
- 参与的国家自然科学基金重大研究计划培育项目算不算限项里面？
已经有5人回复
- 【求助完结】请问，研究计划，老板签字之后扫描传给我，可行吗？
已经有10人回复
- 【求助】悬赏！攻博需不需要在研究计划里面写回国计划？
已经有31人回复
- 【交流讨论】公派攻博研究计划
已经有9人回复
- 【求助】请问联培的虫友们，有了研修计划，还需要写论文开题报告么
已经有6人回复
- 浙江省2011年度省公益性技术应用研究计划项目开始申报
已经有13人回复
- 填写项目研究计划书注意事项
已经有75人回复
- 别为了小基金没中发愁，这才是大蛋糕——重大研究计划项目指南及申请注意事项
已经有10人回复
- 【版内资源】签证指南直通车（各国签证资源、经验分享汇总）
已经有24人回复
3楼2010-10-30 23:35:28
2楼2010-10-30 21:26:28
4楼2010-10-31 17:20:28
6楼2010-11-01 10:12:57
50