| 查看: 933 | 回复: 7 | ||
| 本帖产生 1 个 博学EPI ，点击这里进行查看 | ||
whb265金虫 (小有名气)
|
[求助]
求助Boc亚胺的合成方法
|
|
求助Boc亚胺的合成方法 |
回复此楼» 猜你喜欢
招收生物学/细胞生物学调剂
已经有4人回复
-
一志愿武汉理工，总分321，英一数二，求老师收留。
已经有5人回复
-
324求调剂
已经有8人回复
-
284求调剂
已经有12人回复
-
348求调剂
已经有3人回复
-
329求调剂
已经有7人回复
-
求调剂，一志愿 南京航空航天大学大学 ，080500材料科学与工程学硕
已经有4人回复
-
考研调剂
已经有9人回复
-
304材料求调剂
已经有4人回复
-
一志愿郑大085600，310分求调剂
已经有3人回复
whb265
金虫 (小有名气)
- 应助: 0 (幼儿园)
- 金币: 2.8
- 散金: 5
- 帖子: 221
- 在线: 124.3小时
- 虫号: 637859
- 注册: 2008-10-27
- 专业: 高分子物理与高分子物理化
2楼2010-10-26 18:42:01
121918051
至尊木虫 (著名写手)
- 博学EPI: 12
- 应助: 1 (幼儿园)
- 金币: 10941.1
- 散金: 30
- 红花: 17
- 帖子: 2764
- 在线: 634.8小时
- 虫号: 999319
- 注册: 2010-04-17
- 专业: 有机合成
3楼2010-10-27 09:29:56
121918051
至尊木虫 (著名写手)
- 博学EPI: 12
- 应助: 1 (幼儿园)
- 金币: 10941.1
- 散金: 30
- 红花: 17
- 帖子: 2764
- 在线: 634.8小时
- 虫号: 999319
- 注册: 2010-04-17
- 专业: 有机合成
4楼2010-10-27 12:47:45
whb265
金虫 (小有名气)
- 应助: 0 (幼儿园)
- 金币: 2.8
- 散金: 5
- 帖子: 221
- 在线: 124.3小时
- 虫号: 637859
- 注册: 2008-10-27
- 专业: 高分子物理与高分子物理化
5楼2010-10-29 09:28:39
寒月龙飞
木虫 (小有名气)
- 应助: 0 (幼儿园)
- 金币: 1789.1
- 帖子: 214
- 在线: 105.1小时
- 虫号: 346841
- 注册: 2007-04-15
- 性别: GG
- 专业: 化学生物学与生物有机化学
【答案】应助回帖
|
两步做：先合成氨基亚砜类化合物，第二部用碳酸钾催化脱去亚磺酸集团。一 A 500-mL flask was charged with tert-butyl carbamate (10.0 g, 85.5 mmol, 1.00 equiv) and benzenesulfinic acid sodium salt (28 g, 170 mmol, 2.0 equiv). Solids were suspended in a solution of methanol in water (1:2, 250 mL). Benzaldehyde (13.0 mL, 128 mmol, 1.50 equiv) was then added in one portion, followed by formic acid (98%, 6.4 mL). The reaction was allowed to stir 48 h at 23 °C, during which time the product precipitated as a white solid. which was isolated via Büchner funnel filtration and purified via trituration with water and diethyl ether. After drying in vacuo, 7a was obtained as a white solid (23.6 g, 80%).二 A 250-mL, 3-neck flask was charged with anhydrous potassium carbonate (12.4 g, 90.0 mmol, 6.00 equiv) and anhydrous sodium sulfate (15 g). The solids were placed under vacuum and flame-dried. Once cool, 7a (5.2 g, 15 mmol, 1.0 equiv) was added under a positive stream of nitrogen, followed by anhydrous tetrahydrofuran (140 mL). The flask was capped with a water-cooled reflux condenser under an atmosphere of nitrogen and heated to reflux with stirring. After 15 h, the reaction was cooled to ambient temperature and the solids removed via filtration through a fine, glass frit. The filtrate was concentrated in vacuo and dried under high vacuum to give imine as a colorless oil |
6楼2010-11-08 20:24:51
寒月龙飞
木虫 (小有名气)
- 应助: 0 (幼儿园)
- 金币: 1789.1
- 帖子: 214
- 在线: 105.1小时
- 虫号: 346841
- 注册: 2007-04-15
- 性别: GG
- 专业: 化学生物学与生物有机化学
7楼2010-11-08 20:26:23
寒月龙飞
木虫 (小有名气)
- 应助: 0 (幼儿园)
- 金币: 1789.1
- 帖子: 214
- 在线: 105.1小时
- 虫号: 346841
- 注册: 2007-04-15
- 性别: GG
- 专业: 化学生物学与生物有机化学
8楼2010-11-08 20:28:11
