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Each herbal drug has to be HPLC-fingerprinted and the main compounds determined. After mixing the individual components (powder/extract?) in the ratio given in Table 1 the whole mixture has to be once more fingerprinted by 3D-HPLC-analysis. Some batches of the formula XXX have to be investigated to prove whether the composition can be reproduced by HPLC-analysis with not more than 5% deviation .
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We acknowledge the receipt of your revised manuscript. The revised manuscript was improved but you have forgotten to include the HPLC-fingerprints of the single herbal extracts as shown in the first version (Fig. 1). Were the conditions (solvent systems and gradient) the same and at which wavelength were the HPLC-fingerprints of the single components recorded? Please write in the title, in the Abstract and Keywords that the XXX is a fixed combination which in prescription is not individually changed in the ratio of herbal comonents.
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