| ²é¿´: 1721 | »Ø¸´: 9 | |||
lshytľ³æ (ÕýʽдÊÖ)
|
[½»Á÷]
Ó¢Ò뺺ÇóÖúÒ»¾ä»°£¡£¡£¡¼±Ð裡£¡£¡
|
|
:opharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit |
» ²ÂÄãϲ»¶
288×ÊÔ´Óë»·¾³×¨Ë¶Çóµ÷¼Á£¬²»ÏÞרҵ£¬ÓÐѧÉϾÍÐÐ
ÒѾÓÐ6È˻ظ´
ÉúÎïѧѧ˶£¬Ò»Ö¾Ô¸ºþÄÏ´óѧ£¬³õÊԳɼ¨338
ÒѾÓÐ8È˻ظ´
266·Ö£¬Çó²ÄÁÏÏà¹Ø×¨Òµµ÷¼Á
ÒѾÓÐ6È˻ظ´
304²ÄÁÏÇóµ÷¼Á
ÒѾÓÐ5È˻ظ´
359Çóµ÷¼Á
ÒѾÓÐ5È˻ظ´
085600 286·Ö ²ÄÁÏÇóµ÷¼Á
ÒѾÓÐ12È˻ظ´
¸÷λÀÏʦºÃ£¬ÎÒµÄһ־ԸΪ±±¾©¿Æ¼¼´óѧ085601²ÄÁÏר˶
ÒѾÓÐ10È˻ظ´
Ò»Ö¾Ô¸£ºÎ÷±±´óѧ£¬Ó¢Ò»ÊýÒ»408-284·ÖÇóµ÷¼Á
ÒѾÓÐ5È˻ظ´
291Çóµ÷¼Á
ÒѾÓÐ10È˻ظ´
Ò»Ö¾Ô¸Ö£ÖÝ´óѧ£¬080500ѧ˶£¬×Ü·Ö317·ÖÇóµ÷¼Á
ÒѾÓÐ11È˻ظ´

YYxiuyu
ľ³æ (СÓÐÃûÆø)
- ·ÒëEPI: 42
- Ó¦Öú: 0 (Ó×¶ùÔ°)
- ½ð±Ò: 2158.7
- É¢½ð: 351
- ºì»¨: 1
- Ìû×Ó: 143
- ÔÚÏß: 51.3Сʱ
- ³æºÅ: 951537
- ×¢²á: 2010-02-02
- ÐÔ±ð: GG
- רҵ: ½ðÊô½á¹¹²ÄÁÏ
2Â¥2010-09-29 01:09:47
lshyt
ľ³æ (ÕýʽдÊÖ)
- Ó¦Öú: 3 (Ó×¶ùÔ°)
- ¹ó±ö: 0.05
- ½ð±Ò: 5295.3
- É¢½ð: 55
- ºì»¨: 10
- Ìû×Ó: 638
- ÔÚÏß: 209Сʱ
- ³æºÅ: 982289
- ×¢²á: 2010-03-25
- ÐÔ±ð: GG
- רҵ: Ò©Îﻯѧ

3Â¥2010-09-29 08:57:38
YYxiuyu
ľ³æ (СÓÐÃûÆø)
- ·ÒëEPI: 42
- Ó¦Öú: 0 (Ó×¶ùÔ°)
- ½ð±Ò: 2158.7
- É¢½ð: 351
- ºì»¨: 1
- Ìû×Ó: 143
- ÔÚÏß: 51.3Сʱ
- ³æºÅ: 951537
- ×¢²á: 2010-02-02
- ÐÔ±ð: GG
- רҵ: ½ðÊô½á¹¹²ÄÁÏ
4Â¥2010-09-29 09:37:41
¹Å¿É¤×
ÈÙÓþ°æÖ÷ (ÎÄ̳¾«Ó¢)
- ·ÒëEPI: 323
- Ó¦Öú: 91 (³õÖÐÉú)
- ¹ó±ö: 16.835
- ½ð±Ò: 19237.1
- É¢½ð: 40372
- ºì»¨: 275
- ɳ·¢: 183
- Ìû×Ó: 25406
- ÔÚÏß: 1082.3Сʱ
- ³æºÅ: 1034379
- ×¢²á: 2010-06-02
- ÐÔ±ð: GG
- רҵ: Ò©ÎïÉè¼ÆÓëÒ©ÎïÐÅÏ¢
- ¹ÜϽ: µ¼Ê¦ÕÐÉú
¡ï ¡ï ¡ï
·¢Ñ¿ÍÁ¶¹(½ð±Ò+1):лл²ÎÓë 2010-10-01 09:29:09
ringzhu(½ð±Ò+2): 2010-11-22 13:34:29
·¢Ñ¿ÍÁ¶¹(½ð±Ò+1):лл²ÎÓë 2010-10-01 09:29:09
ringzhu(½ð±Ò+2): 2010-11-22 13:34:29
|
ÓÃßÁ¿©Íéͪ¿ØÊͱ½ÒÒ°·£ºÊÇÒÔÈöÍøÊ½µÄ·½·¨Ë§Ñ¡³öÄÜÉè¼ÆÎª¾ßÓÐǿЧ¡¢°ÐλѡÔñÐÔÒÔ¼°¶þëÄ»ùëÄøIV£¨DPP4£©ÒÖÖÆ¼ÁҩЧ×÷ÓõÄмÁÐÍ¡£ |

5Â¥2010-09-29 20:58:12
rbhuang
ľ³æ (ÕýʽдÊÖ)
- ·ÒëEPI: 9
- Ó¦Öú: 0 (Ó×¶ùÔ°)
- ½ð±Ò: 2889.2
- Ìû×Ó: 692
- ÔÚÏß: 362.3Сʱ
- ³æºÅ: 5145
- ×¢²á: 2003-03-29
- ÐÔ±ð: GG
- רҵ: ÊýѧÎïÀí
¡ï
·¢Ñ¿ÍÁ¶¹(½ð±Ò+1):лл²ÎÓë 2010-10-01 09:29:16
·¢Ñ¿ÍÁ¶¹(½ð±Ò+1):лл²ÎÓë 2010-10-01 09:29:16
|
È«´íÁË£¡£¡ ¾ä×ӽṹÊÇÕâÑùµÄ£º 1. ±¾ÎÄÕµÄÌâÄ¿ÖÐÖ÷ÓïÊÇʲô£¿ ´ð£ºÎÄÕÂÌâÄ¿ÖØÒª¾ÍÊÇPyrrolidine-constrained phenethylamines 2. ÄÇôPyrrolidine-constrained phenethylaminesÓÖÊÇʲô¶«Î÷£¿ ´ð£ºËüÊÇÒ»ÖÖҩЧǿ¡¢Ñ¡ÔñÐԺá¢Ò©ÀíѧÊÔÑé¸ß¶ÈÓÐЧµÄIVÐͶþëĵ°°×ø(¼ò³ÆDPP4£©µÄÒÖÖÆ¼Á£¨potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV(DPP4)£©¡£ 3. ¸ÃÒÖÖÆ¼ÁÊÇ´ÓÄÄÀï·¢Ïֵģ¿ ´ð£º ÊÇͨ¹ýÒ»´ÎÏȵ¼Ò©ÎïɸѡµÄÃüÖнá¹û£¨a lead-like screening hit£©ÖÐÑ¡µ½µÄ¡£ 4. ÄÇÕâ¸öÌâĿժҪ½²Ð©Ê²Ã´£¿ ´ð£ºÕªÒª¾ÍÊǽ²Õâ¸öÒÖÖÆÎïµÄÉè¼Æ£¨The design of ..... inhibitors)¡£ |
6Â¥2010-09-30 04:27:24
rbhuang
ľ³æ (ÕýʽдÊÖ)
- ·ÒëEPI: 9
- Ó¦Öú: 0 (Ó×¶ùÔ°)
- ½ð±Ò: 2889.2
- Ìû×Ó: 692
- ÔÚÏß: 362.3Сʱ
- ³æºÅ: 5145
- ×¢²á: 2003-03-29
- ÐÔ±ð: GG
- רҵ: ÊýѧÎïÀí
|
È«´íÁË£¡£¡ ¾ä×ӽṹÊÇÕâÑùµÄ£º 1. ±¾ÎÄÕµÄÌâÄ¿ÖÐÖ÷ÓïÊÇʲô£¿ ´ð£ºÎÄÕÂÌâÄ¿Ö÷Òª¾ÍÊÇPyrrolidine-constrained phenethylamines 2. ÄÇôPyrrolidine-constrained phenethylaminesÓÖÊÇʲô¶«Î÷£¿ ´ð£ºËüÊÇÒ»ÖÖҩЧǿ¡¢Ñ¡ÔñÐԺá¢Ò©ÀíѧÊÔÑé¸ß¶ÈÓÐЧµÄIVÐͶþëĵ°°×ø(¼ò³ÆDPP4£©µÄÒÖÖÆ¼Á£¨potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV(DPP4)£©¡£ 3. ¸ÃÒÖÖÆ¼ÁÊÇ´ÓÄÄÀï·¢Ïֵģ¿ ´ð£º ÊÇͨ¹ýÒ»´ÎÏȵ¼Ò©ÎïɸѡµÄÃüÖнá¹û£¨a lead-like screening hit£©ÖÐÑ¡µ½µÄ¡£ 4. ÄÇÕâ¸öÌâÄ¿Ö÷Òª½²Ð©Ê²Ã´£¿ ´ð£ºÖ÷Òª¾ÍÊǽ²Õâ¸öÒÖÖÆÎïµÄÉè¼Æ£¨The design of ..... inhibitors)¡£ |
7Â¥2010-09-30 04:29:33
¹Å¿É¤×
ÈÙÓþ°æÖ÷ (ÎÄ̳¾«Ó¢)
- ·ÒëEPI: 323
- Ó¦Öú: 91 (³õÖÐÉú)
- ¹ó±ö: 16.835
- ½ð±Ò: 19237.1
- É¢½ð: 40372
- ºì»¨: 275
- ɳ·¢: 183
- Ìû×Ó: 25406
- ÔÚÏß: 1082.3Сʱ
- ³æºÅ: 1034379
- ×¢²á: 2010-06-02
- ÐÔ±ð: GG
- רҵ: Ò©ÎïÉè¼ÆÓëÒ©ÎïÐÅÏ¢
- ¹ÜϽ: µ¼Ê¦ÕÐÉú

8Â¥2010-09-30 19:53:58
¹Å¿É¤×
ÈÙÓþ°æÖ÷ (ÎÄ̳¾«Ó¢)
- ·ÒëEPI: 323
- Ó¦Öú: 91 (³õÖÐÉú)
- ¹ó±ö: 16.835
- ½ð±Ò: 19237.1
- É¢½ð: 40372
- ºì»¨: 275
- ɳ·¢: 183
- Ìû×Ó: 25406
- ÔÚÏß: 1082.3Сʱ
- ³æºÅ: 1034379
- ×¢²á: 2010-06-02
- ÐÔ±ð: GG
- רҵ: Ò©ÎïÉè¼ÆÓëÒ©ÎïÐÅÏ¢
- ¹ÜϽ: µ¼Ê¦ÕÐÉú
|
£ººóÃæÖ÷ÒªÊÇÓÃÀ´Ç¿µ÷ßÁ¿©Íéͪ¿ØÊͱ½ÒÒ°·ÕâÖ÷ÓïµÄ£¬ËùÒÔżÈÏΪÊÇÕâÑù£¬¾ÍÊÇlead-like Ôõô·ÒëÖµµÃÕå×㬷´ÕýÊÇÒ»ÖÖ˧ѡ·½·¨£¬¶ø²»ÊÇËùνµÄÏȵ¼»¯ºÏÎïµÄ£¬Ö÷ÓïµÄÒâ˼¾ÍÊÇÓÃßÁ¿©Íéͪ¿ØÊͱ½ÒÒ°·¡£lead-like screening hit ±ÉÈËÈÏΪ ¾ÍÊÇÏñÀ×ÅÍøÈ¥Ë§Ñ¡ ÓÃßÁ¿©Íéͪ¿ØÊͱ½ÒÒ°·£ºÊÇÒÔÈöÍøÊ½µÄ·½·¨Ë§Ñ¡³öÄÜÉè¼ÆÎª¾ßÓÐǿЧ¡¢°ÐλѡÔñÐÔÒÔ¼°¶þëÄ»ùëÄøIV£¨DPP4£©ÒÖÖÆ¼ÁҩЧ×÷ÓõÄмÁÐÍ¡£ |

9Â¥2010-09-30 20:05:14
rbhuang
ľ³æ (ÕýʽдÊÖ)
- ·ÒëEPI: 9
- Ó¦Öú: 0 (Ó×¶ùÔ°)
- ½ð±Ò: 2889.2
- Ìû×Ó: 692
- ÔÚÏß: 362.3Сʱ
- ³æºÅ: 5145
- ×¢²á: 2003-03-29
- ÐÔ±ð: GG
- רҵ: ÊýѧÎïÀí
10Â¥2010-10-01 03:03:48














»Ø¸´´ËÂ¥