| 查看: 144 | 回复: 1 | |||
| 当前主题已经存档。 | |||
gaoshandian1金虫 (小有名气)
|
[交流]
适配体蛋白Nck和Fas配基的相互作用
|
||
|
Marcus Lettau, Jing Qian, Andreas Linkermann et al, The Fas ligand (FasL) is a key death factor of cytotoxic T lymphocytes and natural killer cells. It is stored intracellularly as a transmembrane protein of secretory lysosomes. Upon activation, these vesicles are transported to the cytotoxic immunological synapse (IS), and FasL becomes exposed to the cell surface to trigger cell death through ligation of its receptor Fas (CD95) on the target cell. We propose that the FasL-associated adaptor protein Nck is involved in the actin-dependent transport of FasL-bearing secretory lysosomes to the IS. Nck binds to the proline-rich portion of FasL and alters its subcellular distribution when coexpressed in 293T cells. In T lymphocytes, endogenous Nck partially colocalizes with lysosome-associated FasL. When T cell clones or lines are exposed to target cells, both proteins and other components of secretory lysosomes (i.e., granzyme B or cathepsin D) are transported to the cell-cell interface. The present data suggest that T cell receptor engagement provokes a rapid, tyrosine kinase- and actin-dependent transport of Nck-associated FasL-carrying lysosomes to the contact area. Our observations support the previous notion that the unique cytoplasmic tail of FasL is crucial for its directed transport to the cell surface and into the assembling cytotoxic IS. ------------------------------------ PNAS | April 11, 2006 | vol. 103 | no. 15 | 5911-5916 全文链接 |
回复此楼» 猜你喜欢
围手术期管理：麻醉专家网络研讨系列会
已经有0人回复
-
问问各位经验者
已经有1人回复
-
微生物学论文润色/翻译怎么收费?
已经有184人回复
-
医学影像三维立体解剖图谱
已经有0人回复
-
直面医事危机住院医师的人生“大考”
已经有0人回复
-
中医学学习指导习题集（第2版）
已经有0人回复
-
内分泌常见疾病专家答疑
已经有0人回复
-
重症医学科诊疗要点-杨殿武-2019
已经有0人回复
-
重症医学科诊疗实践
已经有0人回复
-
重症医学监护与应用-白静-2021
已经有0人回复
-
刘志远教授课题组博士招生｜深理工×宁波诺丁汉大学联合培养项目
已经有0人回复
1
 |
2楼2006-05-11 09:22:51
