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| There was also a lineage fate change of BM HSCs in bleeding mice that was manifested in increased megakaryocyte-erythrocyte progenitors (MEPs) and periodically reduced granulocyte-macrophage progenitors (GMPs) in the BM, up-regulated erythroid-specific GATA-1 and down-regulated granulocyte-macrophage-specific PU.1 mRNA expression in the LSK subset, and the capacity of LSK cells to differentiate into more erythroid precursors after culture. |
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ringzhu(金币+2, 翻译EPI+1): 2010-11-22 12:19:14
ringzhu(金币+2, 翻译EPI+1): 2010-11-22 12:19:14
| There was also a lineage fate change of BM HSCs in bleeding mice. This change was manifested in many ways as follow.Firstly megakaryocyte-erythrocyte progenitors (MEPs) was increased.Secondly granulocyte-macrophage progenitors (GMPs) in the BM was periodically reduced.Thirdly erythroid-specific GATA-1 was up-regulated. Forthly granulocyte-macrophage-specific PU.1 mRNA expression in the LSK subset was down-regulated. Besides LSK cells differentiated into more erythroid precursors after culture. |
2楼2010-09-26 16:06:55