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【资源】Cancer: Predictions in lymphoma
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The presence of a specific cell type in people with lymphoma is negatively associated with survival, providing a new biomarker with potential clinical applications (Proc. Natl. Acad. Sci. USA 107, 12747–12754). Jonathan Irish et al. used single-cell profiling in samples of human follicular lymphoma and found a subset of lymphoma cells with defective B cell antigen receptor (BCR) signaling. Jonathan Irish The more of these cells in each tumor, the shorter the overall subject survival. Moreover, these lymphoma cells increased in number as tumors relapsed after chemotherapy. Interestingly, BCR signaling could be reactivated in the defective cells, indicating that BCR signaling was not altogether absent but somehow suppressed. Mechanistically, tumors with high counts of defective BCR cells had less interleukin-7 signaling in infiltrating T cells, but additional work will be required to understand how these cells emerge and what their downstream effects are. In addition to representing a potential biomarker, the existence of cells with defective BCR signaling may provide new targets against follicular lymphoma.—JCL |
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癌症：淋巴瘤中的预测因子 淋巴瘤病人中特异细胞类型的存在与病人的生存呈负相关，该发现可提供一种新的生物标记物，并具有潜在的临床意义。 在滤泡性淋巴瘤样本中使用单细胞仿形切削技术发现了一些具有缺陷B细胞抗原受体（BCR）信号的淋巴瘤细胞。每个肿瘤中这些细胞越多，病人的生存期越短。而且，当化疗后肿瘤复发时这些淋巴瘤细胞数量上增加。令人感兴趣的是，在这些缺陷细胞中BCR信号可能重新活化，提示BCR信号不是一起缺乏而是有些被抑制了。 机制上，伴有较高数量缺陷BCR的肿瘤在浸润的T细胞中较少表达IL-7信号，但需要另外的工作来理解这些细胞是如何出现的和它们的下游效应是什么。 除了代表潜在的生物标记物外，伴有缺陷BCR信号的细胞存在可提供滤泡性淋巴瘤新的靶点。 |
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