| 查看: 390 | 回复: 2 | |||
| 当前主题已经存档。 | |||
徐亚萍金虫 (正式写手)
|
[交流]
新药-比伐卢定 大家讨论一下
|
||
|
比伐卢定:这种药除了上海子能制药还有别的生产厂家吗？它与蛇毒凝血酶是不是一种东西， 比伐卢定 [128270-60-0] Purity (HPLC) ≥98% D-Phe-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu 合成工艺：Monograph Number: 1306 Title: Bivalirudin CAS Registry Number: 128270-60-0 Additional Names: Hirulog-1; hirulog-8 Manufacturers' Codes: BG-8967 Trademarks: Angiomax (Medicines Co.); Hirulog (Biogen) Molecular Formula: C98H138N24O33 Molecular Weight: 2180.28. Percent Composition: C 53.99%, H 6.38%, N 15.42%, O 24.22% Literature References: Synthetic peptide of 20 amino acids; member of a novel class of bivalent thrombin inhibitors. Characterized by an anion binding exosite (ABE) derived from hirudin, q.v., linked to a thrombin catalytic site inhibitor moiety by tetraglycine. Prepn and structure activity study: J. M. Maraganore et al., WO 91 02750; eidem, US 5196404 (1991, 1993 both to Biogen); eidem, Biochemistry 29, 7095 (1990). Determn in plasma and whole blood: T. J. Reid, B. M. Alving, Thromb. Haemostasis 70, 608 (1993). Clinical pharmacology: I. Fox et al., ibid. 69, 157 (1993). Clinical study in myocardial infarction: P. Théroux et al., Circulation 91, 2132 (1995); during coronary angioplasty: J. A. Bittl et al., N. Engl. J. Med. 333, 764 (1995). Review of antithrombotic activity and clinical evaluation: J. M. Maraganore, Perspect. Drug Discovery Design 1, 461-478 (1993). Therap-Cat: Antithrombotic. RCB_CT,74865Entry Name: Bivalirudin, BAN, INN, USAN Synonym(s): Hirulog I. Angiomax. BG 8967 Chapman Hall Number: NCZ48-N CAS Registry Number: 128270-60-0 Type of Compound Code(s): XA2290 XA4500 XA1350 H-D-Phe-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-OH Molecular Formula: C98H138N24O33 Molecular Weight: 2180.309 Accurate Mass: 2178.985821 Percentage Composition: C 53.99%; H 6.38%; N 15.42%; O 24.22% Biological Use/Importance: Anticoagulant. Haemostatic agent Development Status: Approved by FDA References: Maraganore, J.M. et al., Biochemistry, 1990, 29, 7095, (synth, pharmacol) Skrzypczak-Jankun, E. et al., J. Mol. Biol., 1991, 221, 1379, (struct) Pat. Coop. Treaty (WIPO), 1991, 91 02 750 (Biogen); CA, 115, 150383j, (synth, pharmacol) Maraganore, J.M., Adv. Exp. Med. Biol., 1993, 340, 227, (rev) Roemisch, J. et al., Haemostasis, 1993, 23, 249, (pharmacol) Fox, I. et al., Thromb. Haemostasis, 1993, 69, 157, (pharmacol) Johnson, P.H., Annu. Rev. Med., 1994, 45, 165, (rev) Scatena, R., Expert Opin. Invest. Drugs, 2000, 9, 1119-1127, (rev) Carswell, C.I. et al., Drugs, 2002, 62, 841-870, (rev 新人，需鼓励 [ Last edited by 小小强 on 2006-5-18 at 22:37 ] |
回复此楼» 猜你喜欢
292药学调剂
已经有1人回复
-
广西医科大学基础医学院自身免疫病课题组招收基础医学相关专业的调剂研究生
已经有2人回复
-
药理学论文润色/翻译怎么收费?
已经有202人回复
-
药学专硕申博
已经有18人回复
-
可能上不了岸？有条件的可以考虑其他出路
已经有0人回复
-
广西医科大学基础医学院招收基础医学、药学、生物检验相关专业的研究生
已经有1人回复
-
分子对接相关经验分享
已经有0人回复
-
分子对接相关经验分享
已经有0人回复
-
2026生物医药产业发展大会
已经有0人回复
-
国青中了
已经有23人回复
1
 |
2楼2006-04-27 06:43:27
0.5
 |
3楼2006-04-28 14:38:49
30