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madai26

银虫 (小有名气)

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金币: 923.7
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虫号: 231201
注册: 2006-03-27
性别: MM
专业: 药物设计与药物信息

[交流] 【求助】有没有虫子帮我查一下fasidotril这个药在国外有没有上市？已有2人参与

因为我们单位没啥数据库，所以查不到。

fasidotril 法西多曲
ACE/NEP双向抑制剂

临床试验做到3期，但后来就没下文了，哪位好心的虫子帮个忙呢？帮我把它有没有上市，在哪上市的查一下？

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1楼 2010-08-04 11:31:02

已阅回复此楼关注TA 给TA发消息送TA红花 TA的回帖

nkbeholder

木虫 (正式写手)

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虫号: 202353
注册: 2006-03-01
性别: GG
专业: 药物化学

★ ★
madai26(金币+2):谢谢参与
warlen(金币+1):谢谢参与 2010-08-04 15:15:09

这上面写到2期就中止了。

Originator Company: Bioprojet (France)
Parent Company: Bioprojet
Licensee: Eli Lilly

Highest Phase: Discontinued II

Development Status:

Discontinued II, France, Congestive heart failure
Discontinued II, France, Hypertension
Discontinued Preclinical, France, Postmyocardial infarction
Introduction:
Fasidotril, the prodrug of its active metabolite fasidoprilat, is a mixed inhibitor of ACE and neutral endopeptidase. It was undergoing phase II development with Bioprojet in France for the treatment of congestive heart failure and hypertension. It was also in preclinical development for postmyocardial infarction. However, development appears to have been discontinued.

In October 2001, Bioprojet and Eli Lilly announced a development and commercialisation collaboration. Under the terms of the agreement, Lilly received exclusive worldwide commercialisation rights excluding Japan and certain countries in Europe. Lilly was to continue to develop fasidotril through to registration, and was to manufacture the finished product; Bioprojet was to manufacture the bulk material.