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mhwu514(½ð±Ò+1):ллÌÖÂÛ 2010-08-25 11:30:08
Nano Today (2009) 4, 359¡ª373

REVIEW
Synthesis and biomedical applications of
hollow nanostructures
Kwangjin An, Taeghwan Hyeon∗
National Creative Research Initiative Center for Oxide Nanocrystalline Materials and School of Chemical and
Biological Engineering, Seoul National University, Seoul 151-744, Republic of Korea
Received 18 May 2009; received in revised form 25 June 2009; accepted 30 June 2009

Summary Hollow nanostructures have attracted tremendous attention from researchers in
various disciplines because their high surface to volume ratio and large pore volume are highly
desirable for many technological applications including drug delivery system. Several colloidal
synthetic methods have been used to synthesize various hollow nanostructures. These
synthetic approaches are mainly categorized into four main classes according to how the hollow
structure is formed: the Kirkendall effect, chemical etching, galvanic replacement, and
template-mediated approach. The large pores inside the hollow nanostructures can encapsulate
and release various drugs and biomolecules, while the surface of the nanostructure can be
functionalized for drug targeting or bio-labeling. These features make the hollow nanostructures
a unique and promising candidate as multifunctional drug delivery vehicles. This review
article covers recent progress concerning the synthesis of hollow nanostructures with their sizes
smaller than 200nm and their biomedical applications including specific targeting, imaging, and
controlled release of therapeutics for simultaneous diagnosis and therapy.
© 2009 Elsevier Ltd. All rights reserved.
7Â¥2010-08-25 10:35:58
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wangyang7887

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28129651(½ð±Ò+1): 2010-06-27 20:13:51
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28129651(½ð±Ò+1): 2010-06-28 10:32:14
Yurong Ma and Limin Qi, ¡°Solution-phase synthesis of inorganic hollow structures by templating strategies¡±, J. Colloid Interface Sci. 2009, 335, 1-10.
4Â¥2010-06-28 09:40:45
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