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求助英译汉（5月26日中午12点前完成有效）
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1、Irinotecan is an antineoplastic enzyme inhibitor primarily used in the treatment of colorectal cancer. Irinotecan is a derivative of camptothecin. Irinotecan inhibits the action of topoisomerase I. Irinotecan prevents religation of the DNA strand by binding to topoisomerase I-DNA complex, and causes double-strand DNA breakage and cell death. 2、Decitabine is indicated for treatment of patients with myelodysplastic syndrome (MDS). It is a chemical analogue of cytidine, a nucleoside present in DNA and RNA. Cells in the presence of Decitabine incorporate it into DNA during replication and RNA during transcription. The incorporation of Decitabine into DNA or RNA inhibits methyltransferase thereby causing demethylation in that sequence. This adversely affects the way that cell regulatory proteins are able to bind to the DNA/RNA substrate. 3、Pimecrolimus is a chemical that is used to treat atopic dermatitis (eczema). Atopic dermatitis is a skin condition characterized by redness, itching, scaling and inflammation of the skin. The cause of atopic dermatitis is not known; however, scientists believe that it may be due to activation of the immune system by various environmental or emotional triggers. Scientists do not know exactly how pimecrolimus reduces the manifestations of atopic dermatitis, but pimecrolimus reduces the action of T-cells and mast cells which are part of the immune system and contribute to responses of the immune system. Pimecrolimus prevents the activation of T-cells by blocking the effects of chemicals (cytokines) released by the body that stimulate T-cells. Pimecrolimus also reduces the ability of mast cells to release chemicals that promote inflammation. 4、Temsirolimus is an inhibitor of mTOR (mammalian target of rapamycin). Temsirolimus binds to an intracellular protein (FKBP-12), and the protein-drug complex inhibits the activity of mTOR that controls cell division. Inhibition of mTOR activity resulted in a G1 growth arrest in treated tumor cells. When mTOR was inhibited, its ability to phosphorylate p70S6k and S6 ribosomal protein, which are downstream of mTOR in the PI3 kinase/AKT pathway was blocked. In in vitro studies using renal cell carcinoma cell lines, temsirolimus inhibited the activity of mTOR and resulted in reduced levels of the hypoxia-inducible factors HIF-1 and HIF-2 alpha, and the vascular endothelial growth factor. 5、Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor. It is currently used as an immunosuppressant to prevent rejection of organ transplants. In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and not on the mTORC2 protein. |
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2楼2010-05-25 23:15:11
aloin(金币+5, 翻译EPI+1):谢谢 2010-05-26 10:22:55
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我只是来学习的，楼主忽略我吧 antineoplastic抗肿瘤的 colorectal cancer大肠癌 camptothecin喜树碱 topoisomerase拓扑异构酶 religation重新连接 recombinant重组 DNA strand DNA链 myelodysplastic syndrome (MDS)骨髓增生异常综合征，原名白血病前期preleukemia cytidine胞嘧啶 nucleoside核苷 incorporate合并、掺进 replication复制 transcription转录 methyltransferase甲基转移酶 adversely affects不利影响 regulatory调节 atopic dermatitis异位性皮肤炎 eczema湿疹 太晚了 都是些药品简介 |
3楼2010-05-26 00:51:30
jingjing1005
木虫 (小有名气)
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aloin(金币+95):谢谢 2010-05-26 10:23:19
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1伊立替康是主要用于治疗结直肠癌的酶抑制剂抗肿瘤药。伊立替康是喜树碱的衍生物。伊立替康抑制拓扑异构酶I的活动，通过形成拓扑异构酶I-DNA复合物阻止DNA单链连接成双链DNA，并导致双链DNA断裂，最终导致细胞死亡。 2 地西他滨用于治疗骨髓增生异常综合征（MDS）。它是一种胞啶的化学类似物，存在于在DNA和RNA的核苷酸中。在地西他滨存在时，细胞分别通过复制过程和转录过程将它整合到DNA和RNA中，从而抑制甲基转移酶的活性，导致该序列脱甲基化。这严重影响了细胞调节蛋白与DNA / RNA基质的结合。 3吡美莫司是一种用于治疗特应性皮炎（湿疹）的药物。异位性皮炎通常有皮肤发红，发痒，鱼鳞和发炎的症状。特应性皮炎的发病原因尚不清楚，但科学家认为它可能是由情绪因素或各种环境因素导致的免疫系激活引起的。科学家并不知道到底吡美莫司是如何缓解特应性皮炎的症状的，但吡美莫司减少了T细胞和肥大细胞的活动，这些细胞是免疫系统的一部分，并在免疫应答过程中起着重要作用。吡美莫司可以阻断人体分泌的化学分子（细胞因子）刺激T细胞活化的过程，同时它还可以抑制肥大细胞释放化学物质，从而减轻炎症症状。 4，驮瑞塞尔Temsirolimus是一种mTOR(哺乳动物的雷帕霉素作用靶点)抑制剂，它可以与一种细胞内蛋白(FKBP一12)相结合，这种蛋白-药物结合物可以抑制mTOR控制细胞分裂。 mTOR可以磷酸化激活p70S6k和S6核糖体蛋白，mTOR下游区的磷脂酰肌醇激酶／AKT(PI3K／AKT)信号转导通路被阻断后，其活性将受到抑制可以使G期的肿瘤细胞生长停滞。采用肾癌细胞为研究对象的体外研究表明，驮瑞塞尔可以抑制mTOR的活性并且降低缺氧诱导因子HIF—l、HIF一2a及血管内皮生长因子水平。 5依维莫司是雷帕霉素衍生物（西罗莫司），与雷帕莫司作用相似，是mTOR（雷帕莫司的作用靶点）的抑制剂。目前用作免疫抑制剂，以防止器官移植的排斥反应。与其他mTOR抑制剂相比，依维莫司只作用于mTORC1蛋白，而对mTORC2蛋白没有影响。 |
4楼2010-05-26 09:49:40