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jinchunlan(金币+10, 翻译EPI+1): 2010-05-18 17:03:29
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By the WenYangFang WenYangLi water cut and come, is the long-term clinical practice cenwanglaoshan herbal preparations of chronic heart failure. The clinical and experimental research confirms the party has good curative effect, can improve cardiac remodeling animal model for heart failure. With chronic heart failure, research progress of the cytokine network in hf myocardial reconstruction is aroused widespread concern. Among Tumor necrosis factor alpha (Tumor necrosis, TNF alpha) in alpha is an important factor of inflammatory cells, promote cell activation cascade as the main medium, in cytokines play an important role in network. Transcription factor - κ B (nuclear κ B, NF - in κ B) is the regulation of gene transcription factors, activate the key to control including TNF alpha, inflammation, as the transcription of integration of the inflammatory response in immune adjustment and inflammation plays an important role in the process. For further discussion WenYangFang efficacy and mechanism, clear in heart failure κ B NF - the role and pathogenesis of TNF alpha adjusting mechanism, this study adopts cell culture and serum pharmacology, WenYangFang method of tumor necrosis factor (TNF alpha) inducing newborn rat cardiac fibroblasts cardial (CFs) proliferation, fibroblasts collagen synthesis, and κ transcription factor NF - expression of B, further discusses its suppression of the molecular myocardial fibrosis, improve cardiac remodeling of heart failure mechanism, so as to its clinical application and development of new medicine to provide scientific theory and evidence. |
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