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hihoney
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包含题目 【题目】A tale of two cannabinoids: The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol 【摘要】This study examines the current knowledge of physiological and clinical effects of tetrahydrocannabinol (THC) and cannabidiol (CBD) and presents a rationale for their combination in pharmaceutical preparations. Cannabinoid and vanilloid receptor effects as well as non-receptor mechanisms are explored, such as the capability of THC and CBD to act as anti-inflammatory substances independent of cyclo-oxygenase (COX) inhibition. CBD is demonstrated to antagonise some undesirable effects of THC including intoxication, sedation and tachycardia, while contributing analgesic, anti-emetic, and anti-carcinogenic properties in its own right. In modern clinical trials, this has permitted the administration of higher doses of THC, providing evidence for clinical efficacy and safety for cannabis based extracts in treatment of spasticity, central pain and lower urinary tract symptoms in multiple sclerosis, as well as sleep disturbances, peripheral neuropathic pain, brachial plexus avulsion symptoms, rheumatoid arthritis and intractable cancer pain. Prospects for future application of whole cannabis extracts in neuroprotection, drug dependency, and neoplastic disorders are further examined. The hypothesis that the combination of THC and CBD increases clinical efficacy while reducing adverse events is supported. [ Last edited by hihoney on 2010-5-7 at 17:49 ] |
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sdywhxlql
金虫 (小有名气)
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hihoney(金币+17, 翻译EPI+1):多谢相助，A tale of two cannabinoids 化用《双城记》的题目是为了说明大麻的两种成分，联合使用会增加药效么。 我如果想说明一种酶具有两种功能，能不能使用a tale of two enzymes?望指教。 http://emuch.net/bbs/viewthread.php?tid=2029922 2010-05-10 22:02:15
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题目：大麻素类报告：四氢大麻酚和大麻二酚联合治疗原理 摘要：本研究探讨四氢大麻酚（THC）和大麻二酚（CBD）的生理和临床疗效并介绍了他们在药品制剂上同时使用的原理。探索Cannabinoid 和 vanilloid 的受体作用和非受体作用的机制，例如THC和CBD作为抗炎底物不受环氧酶（COX）抑制剂的的抑制。CBD表现出对THC的一些副作用表现出拮抗，包括中毒，镇静，心动过速，而对镇痛，反催吐和抗癌表现协同作用。现代临床试验提供了大麻提取物在多发性硬化症中强直性痉挛和中枢性疼痛及泌尿道症状，睡眠障碍，周围神经性疼痛，臂丛症状，风湿性关节炎，顽固性癌性疼痛临床有效性和安全性证据，允许THC的高剂量用法。我们进一步考察了大麻植物整株提取物在神经保护，药物依赖以及肿瘤性疾病方面的未来潜在应用。我们证实了将THC 和CBD联合使用在降低副作用的同时也增加了药物的疗效。 希望对楼主有用 |
4楼2010-05-08 21:17:27
benmao_mogu
木虫 (著名写手)
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2楼2010-05-08 10:31:16
hihoney 
铁杆木虫 (职业作家)
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3楼2010-05-08 12:06:20
