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yyn0452木虫 (正式写手)
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[交流]
求翻译两段话
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First, we computed a correlation matrix for each amino acid: All instances of codons for a given amino acid were extracted, and the identity of the next synonymous codon in the same reading frame was determined. Based on this, the frequency of each possible codon pair was established and compared to the frequency expected under the assumption of random distribution, given the observed codon frequencies (product of individual frequencies). The results were then expressed as number of standard deviations from the expected (Z transform) or percent deviation from the expected,respectively. The autocorrelation results in Table 1 and Table S2 were computed as follows. For each sequence and for each of the nine amino acids with isoaccepting tRNAs (Ala, Arg, Gly, Iso, Leu, Pro, Ser, Thr, and Val) the number of consecutive pairs of codons were counted. The expected number of consecutive pairs was computed as the products of the frequencies of the individual codons of each pair in the database. A Z-transform, subtracting the expected counts from the observed and dividing by the standard deviation (estimated assuming a binomial distribution) was performed and the results expressed as standard deviations from the expected value. The same results were expressed as percentages by subtracting the expected counts from the observed counts and dividing by the expected counts. |
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cszhangdy
木虫 (著名写手)
- 翻译EPI: 1
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- 虫号: 936787
- 注册: 2010-01-04
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sirljz(金币+2):谢谢交流 2010-04-29 17:56
yyn0452(金币+5, 翻译EPI+1): 2010-05-04 09:05
sirljz(金币+2):谢谢交流 2010-04-29 17:56
yyn0452(金币+5, 翻译EPI+1): 2010-05-04 09:05
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第一段： 首先，对于每一个氨基酸，我们计算一个相关矩阵：对于一个给定的氨基酸，提取其所有的遗传密码子，并且其在同一个（reading Frame）内的同义密码子的标识也确定下来了。基于此，可以获取每一个可能的密码子对的频率，同时，假如给定观测到的密码子的频率（各自频率的乘积，）就可以与假设在随机分布的前提下的频率的期望相比较。比较的结果可以各自的表示成期望+- 标准差，或者（标准差/期望）*100%。 [ Last edited by cszhangdy on 2010-4-29 at 17:02 ] |
2楼2010-04-29 16:56:35
yyn0452(金币+10): 2010-05-04 09:05
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首先，我们计算每一个相关的氨基酸矩阵：对于一个给定氨基酸，提取所有的密码子的实例,以及确定同一配对位置的同义密码子的身份。在此基础上，对建立每个可能的密码子配对频率，由观测到的密码子频率（各自频率乘积），就能与随机分布的假设预期频率相比较。结果则表示成期望（Z变换）或偏离预期的百分比标准偏差数 表1和表S2的自相关结果，分别计算如下。对于每个序列和9个与isoaccepting个tRNA（丙氨酸，精氨酸，甘氨酸，异亮氨酸，脯氨酸，丝氨酸，苏氨酸，和缬氨酸）的密码子连续对数个氨基酸进行计数。对预期的连续数计算，作为对数据库中的每个个人密码子配对的频率的乘积。A Z变换，从观测减去预期的数量和除以标准差估计假设一个二项分布（），同时从预期值标准差表示的结果。同样的结果表示为百分比减去预计观察计数计数和计数除以预期。 |
3楼2010-04-30 07:37:34