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wangdandelia

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[交流] 【分享】gene targeting 已有2人参与

What is gene targeting?
     In gene targeting, homologous recombination is used to inactivate a gene in ES cells. An ES cell line is an embryonic stem cell line isolated from a preimplantation mouse embryo. When ES cells are injected into a host embryo, they contribute to the formation of an adult mouse. The extremely rare recombination events of gene targeting can be selected from large numbers of ES cells through the use of genes conferring drug resistance and sensitivity.

http://ko.cwru.edu/services/targeting.html
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silicare

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小木虫(金币+0.5):给个红包,谢谢回帖交流
一个商业机构,不过内容也不错,尤其是主页右上角的小flash
3楼2010-04-23 08:12:36
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wangdandelia

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引用回帖:
Originally posted by silicare at 2010-04-23 08:06:05:
俗称knockout

哇,原来knock out 就是指这个gene targeting啊?我只是个初学者,一直不明白这个概念,呵呵,是根据同源重组替换么?
4楼2010-04-24 14:24:56
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