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zqxia2009铁杆木虫 (正式写手)
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FDA说明书翻译
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Pregnancy Pregnancy Category B: Memantine given orally to pregnant rats and pregnant rabbits during the period of organogenesis was not teratogenic up to the highest doses tested (18 mg/kg/day in rats and 30 mg/kg/day in rabbits, which are 9 and 30 times, respectively, the maximum recommended human dose [MRHD] on a mg/m2 basis). Slight maternal toxicity, decreased pup weights and an increased incidence of nonossified cervical vertebrae were seen at an oral dose of 18 mg/kg/day in a study in which rats were given oral memantine beginning pre-mating and continuing through the postpartum period. Slight maternal toxicity and decreased pup weights were also seen at this dose in a study in which rats were treated from day 15 of gestation through the postpartum period. The no-effect dose for these effects was 6 mg/kg, which is 3 times the MRHD on a mg/m2 basis. |
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melody-yhl
木虫 (著名写手)
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8楼2010-04-17 08:18:44
zqxia2009
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2楼2010-04-16 08:52:20
zqxia2009
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3楼2010-04-16 13:11:55
lastzealot
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4楼2010-04-16 13:19:53
