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志强-药化木虫 (正式写手)
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【求助】急求利舍平合成，书上的太麻烦
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zgykdxzy2006
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麻烦？大师woodward的作品，不麻烦能叫大师吗 去文献区求助 Literature References: Found in Rauwolfia spp. Isoln from the roots of Rauwolfia serpentina L. Benth., Apocynaceae: J. M. Müller et al., Experientia 8, 338 (1952); Dorfman et al., Helv. Chim. Acta 37, 59 (1954); Schwyzer, Mueller, US 2833771 (1958 to Ciba). Structure: Dorfman et al., loc. cit.; Neuss et al., J. Am. Chem. Soc. 76, 2463 (1954). Stereochemistry: Diassi et al., ibid. 77, 2028, 4687 (1955); Huebner, Wenkert, ibid. 4180; van Tamelen, Hance, ibid. 4693; Aldrich et al., ibid. 81, 2481 (1959); Ban, Yonemitsu, Tetrahedron 20, 2877 (1964). Total synthesis: R. B. Woodward et al., J. Am. Chem. Soc. 78, 2023 (1956); eidem, Tetrahedron 2, 1-57 (1958); B. A. Pearlman, J. Am. Chem. Soc. 101, 6404 (1979); P. A. Wender et al., ibid. 102, 6157 (1980). Stereoselective synthesis: G. Stork, Pure Appl. Chem. 61, 439 (1989). Comprehensive description: R. E. Schirmer, Anal. Profiles Drug Subs. 4, 384-430 (1975). Review: A. Scriabine, Ed. in Pharmacology of Antihypertensive Drugs (Raven, New York, 1980) pp 119-125. Review of carcinogenicity studies: IARC Monographs 10, 217-229 (1976); R. M. Diener et al., Toxicol. Pathol. 8, 1-21 (1980). Properties: Long prisms from dil acetone, dec 264-265?(dec 277-277.5?in evac tube). [a]D23 -118?(CHCl3); [a]D26 -164?(c = 0.96 in pyridine); [a]D26 -168?(c = 0.624 in DMF). uv max (CHCl3): 216, 267, 295 nm (e 61700, 17000, 10200). Weak base. pK 6.6. Very sparingly sol in water. Freely sol in chloroform (~1 g/6 ml), methylene chloride, glacial acetic acid. Sol in benzene, ethyl acetate. Slightly sol in acetone, methanol, alcohol (1 g/1800 ml), ether, and in aq solns of acetic and citric acids. Upon standing most solns acquire a yellow color and pronounced fluorescence; esp after the addition of acid or upon exposure to light. |
2楼2010-04-02 23:38:23
liulu19890608
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3楼2010-04-03 00:57:44
