| 查看: 191 | 回复: 2 | |||
| 当前主题已经存档。 | |||
志强-药化木虫 (正式写手)
|
[交流]
【求助】急求利舍平合成，书上的太麻烦
|
||
| 急求利舍平合成，书上的太麻烦 |
回复此楼» 猜你喜欢
研究生做的很差，你们会让毕业吗？
已经有11人回复
-
申博自荐
已经有8人回复
-
26年博士申请自荐-电催化
已经有8人回复
-
求碳排放博导；方向是LCA、生命周期可持续发展以及碳排放
已经有7人回复
-
2026博士申请求助
已经有4人回复
-
2026博士或科研助理转27年博士
已经有7人回复
-
急招2026年9月份入学博士
已经有3人回复
-
2026年博士申请求捞
已经有3人回复
-
国自科送审了吗
已经有11人回复
-
博士招生
已经有5人回复
zgykdxzy2006
金虫 (正式写手)
- 应助: 3 (幼儿园)
- 金币: 91.2
- 散金: 11
- 帖子: 312
- 在线: 129.9小时
- 虫号: 869495
- 注册: 2009-10-12
- 专业: 药物化学
|
麻烦？大师woodward的作品，不麻烦能叫大师吗 去文献区求助 Literature References: Found in Rauwolfia spp. Isoln from the roots of Rauwolfia serpentina L. Benth., Apocynaceae: J. M. Müller et al., Experientia 8, 338 (1952); Dorfman et al., Helv. Chim. Acta 37, 59 (1954); Schwyzer, Mueller, US 2833771 (1958 to Ciba). Structure: Dorfman et al., loc. cit.; Neuss et al., J. Am. Chem. Soc. 76, 2463 (1954). Stereochemistry: Diassi et al., ibid. 77, 2028, 4687 (1955); Huebner, Wenkert, ibid. 4180; van Tamelen, Hance, ibid. 4693; Aldrich et al., ibid. 81, 2481 (1959); Ban, Yonemitsu, Tetrahedron 20, 2877 (1964). Total synthesis: R. B. Woodward et al., J. Am. Chem. Soc. 78, 2023 (1956); eidem, Tetrahedron 2, 1-57 (1958); B. A. Pearlman, J. Am. Chem. Soc. 101, 6404 (1979); P. A. Wender et al., ibid. 102, 6157 (1980). Stereoselective synthesis: G. Stork, Pure Appl. Chem. 61, 439 (1989). Comprehensive description: R. E. Schirmer, Anal. Profiles Drug Subs. 4, 384-430 (1975). Review: A. Scriabine, Ed. in Pharmacology of Antihypertensive Drugs (Raven, New York, 1980) pp 119-125. Review of carcinogenicity studies: IARC Monographs 10, 217-229 (1976); R. M. Diener et al., Toxicol. Pathol. 8, 1-21 (1980). Properties: Long prisms from dil acetone, dec 264-265?(dec 277-277.5?in evac tube). [a]D23 -118?(CHCl3); [a]D26 -164?(c = 0.96 in pyridine); [a]D26 -168?(c = 0.624 in DMF). uv max (CHCl3): 216, 267, 295 nm (e 61700, 17000, 10200). Weak base. pK 6.6. Very sparingly sol in water. Freely sol in chloroform (~1 g/6 ml), methylene chloride, glacial acetic acid. Sol in benzene, ethyl acetate. Slightly sol in acetone, methanol, alcohol (1 g/1800 ml), ether, and in aq solns of acetic and citric acids. Upon standing most solns acquire a yellow color and pronounced fluorescence; esp after the addition of acid or upon exposure to light. |
2楼2010-04-02 23:38:23
liulu19890608
木虫 (小有名气)
- 应助: 2 (幼儿园)
- 金币: 2570
- 散金: 204
- 红花: 2
- 帖子: 291
- 在线: 940.2小时
- 虫号: 445058
- 注册: 2007-10-27
- 专业: 有机合成
3楼2010-04-03 00:57:44