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westwolf木虫 (著名写手)
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有搞生物医学材料的吗！
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westwolf
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是不是发错地方了，这么好好的方向就没有人感兴趣？ 
2楼2006-02-26 12:31:02
sagaman
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3楼2006-02-26 13:12:11
stevenwen
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4楼2006-02-26 13:29:21
westwolf
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5楼2006-02-26 20:34:04
puddingwd
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6楼2006-02-27 23:31:17
westwolf
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自己顶一下,希望有兴趣的朋友加入. 下面是Warwick 大学(英国)生物医学材料课程的教学大纲. The principal aim is to consider various classes of biomaterials (metals, polymers, ceramics, composites and biologic such as collagen) which are capable of mimicking/emulating complicated functions of hard and soft tissues. The subject matter will deal with implanted and tissue engineered materials of various descriptions including prosthesis and external appliances (casts, braces etc). This will also include the replacement of human parts with artificial devices and the problems encountered with the design of these implants. Selected aspects of human physiology will be introduced in order to provide the background necessary to appreciate factors considered critical to govern the selection of biomedical materials. Special emphasis will be placed on the interactive aspects of characterisation of biopolymers and other biomaterials. The areas to be explored are the general relationships between conformation and biological function; essential understanding of the biochemistry of blood and blood-surface interactions; the formation of teeth and bone and the relationships between microstructure; composition and function; the immune responses to implanted materials; the resorption of bone (osteoporosis) and the development of caries. A material perspective will be placed on these topics to explore as to why a material is acceptable or not for a particular application. The design and selection of ceramics for hard tissue prostheses will be described. All orthopedic and dental implants will be explored. Specific bioceramic materials to be discussed include dental porcelain, cements, alumina and zirconia based ceramics, and bioactive glasses (orthopedics and drug delivery), and pyrolytic carbons (heart valves). The theme will be extended, in particular, to Hydroxyapatite (Hap), Hap coatings, Hap-based composites and Hap-metal interactions. Relationships between physical properties, mechanical properties, and chemical interactions with biological fluids will be addressed with reference to the characterisation and analysis of biomaterials. The criteria of how corrosion resistant metal and their alloys are employed will be described with an emphasis on orthopedics. The fracture toughness of metals, their electrochemical responses in-vivo, and the nature of the interfacial interactions with hard tissues will be treated. Metals and alloys such as Ti4AlV, Co-Cr, shape memory alloys (NITINOL) and stainless steels, routinely used in prosthetic applications will be described and their properties as well as limitations discussed. The phenomenon of stress shielding and, in particular, the immune responses associated with the accumulation of metallic and polymeric particulate debris in the vicinity of an implant will be discussed. Polymers are important in a broad range of biomedical applications, notably, soft tissue prostheses, growth promoting agents, dental restoratives, bone replacement materials, and surgical adhesives. The application specific classes of polymers will be considered, i.e. in some instances, a polymer should biodegrade while in others property retention is desirable. Syllabus: Introduction to Biomedical Materials: Historical background, Introduction and overview of biomaterials and biocompatibility. Structure and mechanical properties of tissue, Structure of solids Classes of Biomaterials in Medicine and their manufacture: Metallic, ceramic and polymeric implant materials, Bioglass and glass ceramics, biologic materials, carbons. Manufacturing of ceramics and implants. Tissue Response to Implants: Biocompatibility. Normal wound healing process. Body response to implants. Tissue Replacement: Soft Tissue replacement: Sutures, skin and maxillofacial implants and augmentation. Blood interfacing implants. Hard Tissue replacement: Long bone repair, fracture plates, intramedullary and spinal fixation devices. Fracture healing by electrical and electromagnetic stimulation. Joints (hip, knee, ankle, teeth and other prosthetic devices). Dental implants. Interface problems in orthopaedic implants. Characterisation of Biomaterials: Methods and standards. Mechanical properties. Surface properties and adhesion. Physico-chemical properties. Thermal and viscoelastic properties, Density and porosity. Accoustic and ultrasonic properties. X-ray absorption. Selection, Design and Function of Biomedical Materials for Implants: Bioelectrical and Biomechanical concepts. Biomedical imaging. The flow properties of blood and material-tissue interaction. Tissue Engineering: Scaffolds and skeletal materials. Cell-material interaction. Biomaterial applications, Current technology and future promise. Regulations of Biomedical Devices: European and international perspectives. Introduction of medical devices to market, Platform technology. Venture capital and patents. Licensing. Teaching method: The course consists of : * Sixteen lectures * Twelve seminars * Four tutorial sessions * Two four hour laboratory sessions Illustrative Bibliography : 1. B. D. Ratner, A.S. Hoffman, F.J. Schoen and J.E. Lemons, Biomaterials Science: An Introduction to Materials in Medicine, Academic Press, 1996 2. J.B. Park and R.S. Lake, "Biomaterials: an introduction", 2nd edition, Plenum Press, New York, 1992 3. Larry L Hench and June Wilson, " An introduction to Bioceramics", Advanced series in Ceramics, Vol 1, 1993. 4. John D. Enderle, Susan M. Blanchard and Joseph D. Bronzino, "Introduction to Biomedical Engineering", Academic Press, 2000 [ Last edited by westwolf on 2006-2-27 at 16:00 ] |
7楼2006-02-28 02:13:09
再顾青城
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8楼2006-02-28 03:26:36
stevenwen
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9楼2006-02-28 09:20:21
westwolf
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10楼2006-03-05 04:42:09
