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matvey(金币+1): 2010-04-04 13:05
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Tyrosine kinase inhibitor; highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). Prepn: J. Zimmermann, EP 564409; idem, US 5521184 (1993, 1996 both to Ciba-Geigy); idem et al., Bioorgan. Med. Chem. Letters 7, 187 (1997). Structural mechanism of ABL specificity: T. Schindler et al., Science 289, 1938 (2000). Clinical evaluation in CML: B. J. Drucker et al., N. Engl. J. Med. 344, 1031 (2001); in blast crisis of CML and ALL: eidem, ibid. 1038. |
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