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happykeren2008捐助贵宾 (正式写手)
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求助：一段论文英译汉（3小时内有效）
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| Sample TextAlthough the field of gene delivery is dominated by viral vectors and synthetic polymeric or lipid gene carriers, natural polymers offer distinct advantages and may help advance the field of non-viral gene therapy. Natural polymers, such as chitosan, have been successful in oral and nasal delivery due to their mucoadhesive properties. Collagen has broad utility as gene activated matrices, capable of delivering large quantities of DNA in a direct, localized manner. Most natural polymers contain reactive sites amenable for ligand conjugation, cross-linking, and other modifications that can render the polymer tailored for a range of clinical applications. Natural polymers also often possess good cytocompatibility, making them popular choices for tissue engineering scaffolding applications. The marriage of gene therapy and tissue engineering exploits the power of genetic cell engineering to provide the biochemical signals to influence proliferation or differentiation of cells. Natural polymers with their ability to serve as gene carriers and tissue engineering scaffolds are poised to play an important role in the field of regenerative medicine. This review highlights the past and present research on various applications of natural polymers as particulate and matrix delivery vehicles for gene delivery. |
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happykeren2008(金币+20):谢谢！ 2010-03-19 23:58
| 尽管基因传送是通过病毒载体和合成多聚体，或者脂质基因媒介，天然高分子提供着特有的优势并且可以帮助提高无病毒基因治疗。像壳聚糖那样的天然高分子因为其粘膜粘附能力已经成功地用于口、鼻途径的传送。胶原已作为基因激活的基质被广泛的应用，能以局部方式直接输送大量的基因。大多数天然高分子含有键合、交联及其他修饰作用的反应位点，以适应高分子适应临床上的应用。高分子还有极好的细胞相容性，给组织工程学材料应用提高更为普及的选择。基因治疗的合并和组织工程学开发出强有力的细胞工程，为细胞分化或影响增殖提供生化信号。天然高分子作为基因媒介和组织工程学材料能够对再生医学起重要作用。本综述重点描述了天然高分子作为微粒和基因传送的基质传送工具在过去和目前的研究情况。 |
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3楼2010-03-19 23:09:26