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[交流] 【其他】NATURE---Lessons from 60 years of pharmaceutical innovation_Nature_Munos

Abstract | Despite unprecedented investment in pharmaceutical research and development
(R&D), the number of new drugs approved by the US Food and Drug Administration (FDA)
remains low. To help understand this conundrum, this article investigates the record of
pharmaceutical innovation by analysing data on the companies that introduced the
~1,200 new drugs that have been approved by the FDA since 1950. This analysis shows that
the new-drug output from pharmaceutical companies in this period has essentially been
constant, and remains so despite the attempts to increase it. This suggests that, contrary to
common perception, the new-drug output is not depressed, but may simply reflect the
limitations of the current R&D model. The implications of these findings and options to
achieve sustainability for the pharmaceutical industry are discussed.

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