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In you conclusions, you state "Due to their relative low size at tens of nanometers, Fe3O4/PANI nanoparticles are capable of minimizing reticuloendothelial system (RES) (liver and spleen) uptake upon intravenous injection while having an increased affinity for molecular targets." Nanoparticles (30-50nm) in excess of the glomeri pore size in the kidney (3-5nm) will clear through the liver. Note: Ref 37 states "Enhanced uptake in liver is commonly observed with carbohydrate-modified nanoparticle preparations because of the efficient uptake mechanism into cells of the reticuloendothelial system and the large blood volume and high perfusion of the liver.
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