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细胞色素P450 (Cytochrome P450)是参与昆虫体内各种杀虫剂以及其它外源性和内源性化合物代谢的主要解毒酶系，是微粒体多功能氧化酶（MFO）的末端氧化酶, 有着与底物结合以及从NADPH 传递电子到NADPH 细胞色素P450还原酶的重要功能
Cytochrome P450 (Cytochrome P450) are involved in a variety of insecticides in insects and other exogenous and endogenous compounds, the major detoxification enzymes in metabolism is the microsomal mixed-function oxidase (MFO) of the terminal oxidase, with and substrate binding as well as from the transmission of electronic NADPH to NADPH cytochrome P450 reductase, an important function
因其主要成分 P450蛋白与 CO 的结合体在OD 450 nm处有特征光吸收峰而得名。 Cytochrome P450酶系参与昆虫生长、发育、取食等生理生化过程,指导昆虫对杀虫剂产生抗药性和对植物有毒物质耐受性,包括对植物次生物质代谢和杀虫剂解毒等,有利于昆虫适应不断变化的环境；因其生物学的重要性,该酶一直是生物学研究的一个热点
P450 protein and its major components a combination of CO in the OD 450 nm light at a characteristic absorption peak is named. Cytochrome P450 enzymes involved in insect growth, development, feeding and other physiological and biochemical processes, guiding insects resistant to pesticides and toxic substances tolerance of plants, including plant secondary metabolism and detoxification of pesticides and so on, there are beneficial insects to adapt to the changing environment; its biological importance, the enzyme has been a hot biological research
1967年, Ray首次报道昆虫中存在细胞色素P450基因,随即引起了许多研究者的极大兴趣。由于昆虫体内的细胞色素P450含量偏低、种类繁多且不稳定，难于分离出单一型细胞色素P450等原因，用一般的酶学和生化方法对昆虫单一型的细胞色素P450特性进行深入细致的研究达不到理想效果。自从Feyereisen等(1989)从家蝇(Musca domestica )体内分离出第一个昆虫细胞色素P450基因,由此便进入了从分子水平上对昆虫单一型细胞色素P450的研究。
In 1967, Ray was first reported the existence of insect cytochrome P450 genes, which immediately caused great interest of many researchers. As the insect cytochrome P450 content of the low side, a wide variety and unstable, difficult to isolate a single type of cytochrome P450 and other reasons, to use normal enzymatic and biochemical methods on a single type of insect cytochrome P450 features an in-depth and detailed study of not reach the desired result . Since the Feyereisen et al (1989) from the housefly (Musca domestica) in vivo isolated the first insect cytochrome P450 genes, this will enter the molecular level from a single type of insect cytochrome P450 studies .

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