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lxl8506铜虫 (正式写手)
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800金英译中文章"多酸被证为纳摩尔非竞争性的蛋白激酶CK2抑制剂"23日止
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题目:Identification of Polyoxometalates as Nanomolar Noncompetitive Inhibitors of Protein Kinase CK2 Summary Protein kinase CK2 is a multifunctional kinase of medical importance that is dysregulated in many cancers. In this study, polyoxometalates were identified as original CK2 inhibitors. [P2Mo18O62]6− has the most potent activity. It inhibits the kinase in the nanomolar range by targeting key structural elements located outside the ATP- and peptide substrate-binding sites. Several polyoxometalate derivatives exhibit strong inhibitory efficiency, with IC50 values ≤ 10 nM. Furthermore, these inorganic compounds show a striking specificity for CK2 when tested in a panel of 29 kinases. Therefore, polyoxometalates are effective CK2 inhibitors in terms of both efficiency and selectivity and represent nonclassical kinase inhibitors that interact with CK2 in a unique way. This binding mode may provide an exploitable mechanism for developing potent drugs with desirable properties, such as enhanced selectivity relative to ATP-mimetic inhibitors. PDF图文表共730KB 但总是传不上 联系lxl8506@sina.com 谢谢了 |
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