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ronghui05铜虫 (小有名气)
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[交流]
医学类，谢谢！
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| Gene therapy and viro therapy are among the approaches currently used to treat malignant tumors. Gene therapy and viro therapy use a specific therapeutic gene that causes death in cancer cells. In early attempts at gene therapy, therapeutic genes were driven by ubiquitous promoters such as the CMV promoter, which induce non-specific toxicity to normal cells and tissues in addition to the cancer cells. Recently, novel cancer- and/or tissue-specific promoter systems have been developed to target cancer cells but not normal cells including stem cells. In this review, we describe cancer and/or tissue-specific gene therapy systems for the treatment of cancer. In particular, we will discuss three systems for gene therapy and virotherapy: i) tissue-specific promoter systems, ii) cancer-specific promoter systems, and iii) oncolytic virotherapy. We will also discuss the major challenges of cancer-targeting vector systems and future directions in this area. |
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汪东升wds
新虫 (小有名气)
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ronghui05(金币+3,VIP+0):谢谢！ 1-16 09:49
ronghui05(金币+3,VIP+0):谢谢！ 1-16 09:49
★ ★ ★
ronghui05(金币+3,VIP+0):谢谢！ 1-16 09:49
ronghui05(金币+3,VIP+0):谢谢！ 1-16 09:49