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ronghui05铜虫 (小有名气)
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[交流]
医学类，谢谢！
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| Gene therapy and viro therapy are among the approaches currently used to treat malignant tumors. Gene therapy and viro therapy use a specific therapeutic gene that causes death in cancer cells. In early attempts at gene therapy, therapeutic genes were driven by ubiquitous promoters such as the CMV promoter, which induce non-specific toxicity to normal cells and tissues in addition to the cancer cells. Recently, novel cancer- and/or tissue-specific promoter systems have been developed to target cancer cells but not normal cells including stem cells. In this review, we describe cancer and/or tissue-specific gene therapy systems for the treatment of cancer. In particular, we will discuss three systems for gene therapy and virotherapy: i) tissue-specific promoter systems, ii) cancer-specific promoter systems, and iii) oncolytic virotherapy. We will also discuss the major challenges of cancer-targeting vector systems and future directions in this area. |
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汪东升wds
新虫 (小有名气)
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ronghui05(金币+3,VIP+0):谢谢！ 1-16 09:49
ronghui05(金币+3,VIP+0):谢谢！ 1-16 09:49
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Gene therapy and viro therapy are among the approaches currently used to treat malignant tumors. Gene therapy and viro therapy use a specific therapeutic gene that causes death in cancer cells. In early attempts at gene therapy, therapeutic genes were driven by ubiquitous promoters such as the CMV promoter, which induce non-specific toxicity to normal cells and tissues in addition to the cancer cells. Recently, novel cancer- and/or tissue-specific promoter systems have been developed to target cancer cells but not normal cells including stem cells. In this review, we describe cancer and/or tissue-specific gene therapy systems for the treatment of cancer. In particular, we will discuss three systems for gene therapy and virotherapy: i) tissue-specific promoter systems, ii) cancer-specific promoter systems, and iii) oncolytic virotherapy. We will also discuss the major challenges of cancer-targeting vector systems and future directions in this area. 基因治疗或者病毒治疗是目前对付恶性肿瘤的方法。基因治疗和病毒治疗使用一个能致死癌细胞的特异性治疗基因。在早期的基因治疗试验中，治疗基因是由一个通用的启动子驱动的，比如CMV启动子，它除了可杀死癌细胞外，还可诱导产生针对正常细胞和器官的毒性。最近，新的癌细胞或器官特异性启动子系统已经开发出来，其直指癌细胞，却不影响正常细胞和干细胞。在下文中，我们将会述用于癌症治疗癌细胞或组织特异性启动子系统。我们会专门讨论三个基因或病毒治疗系统：1、器官特异性启动子系统；2、癌细胞特异性启动子系统；3、溶瘤病毒治疗。我们也会讨论目的癌细胞载体系统的主要挑战及这一领域的未来方向 |
2楼2010-01-15 16:21:47
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ronghui05(金币+3,VIP+0):谢谢！ 1-16 09:49
ronghui05(金币+3,VIP+0):谢谢！ 1-16 09:49
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抛砖引玉： 基因治疗和病毒治疗是目前治疗恶性肿瘤方法中的其中两种。基因治疗和病毒治疗是使用一个特异性治疗型基因来杀死癌细胞。在基因治疗使用的早期阶段，一些治疗型基因是由一个通用的启动子驱动的，比如CMV启动子，这样可诱发正常细胞和组织以及癌细胞的非特异性毒性。近来，（科学家）已开发出了新的癌细胞或组织特异性启动子系统，其靶标是癌细胞，但并不影响正常细胞和干细胞。本文我们将介绍用于治疗癌症的癌症或组织特异性启动子系统，尤其是下列三个基因或病毒治疗系统：1、组织特异性启动子系统；2、癌症特异性启动子系统；3、溶瘤病毒治疗。（同时，）我们也会讨论癌症靶向载体系统（面临的）主要挑战及该领域未来的（发展）方向。 |
3楼2010-01-15 20:10:32
