24小时热门版块排行榜

返回列表

当前主题已经存档。

xuqinyao8239

铁杆木虫 (著名写手)

应助: 0 (幼儿园)
金币: 22466
帖子: 2781
在线: 110.5小时
虫号: 310044
注册: 2006-12-23
性别: GG
专业: 有机合成

[交流] 40金币求翻译一段话

In monitoring a reaction it is important to know the reaction “kinetics.”When
developing a process, “kinetics” refers to the rate of formation of the product and
the amount of time needed to reach the desired process endpoint. The goals of
knowing reaction kinetics are to complete processing efficiently and to limit
degradation from overreaction. Periodic in-process monitoring generates the relevant kinetic data.
Changing a parameter can have more than one effect on a process. For
instance, pH is a critical factor in Schotten-Baumann reactions .Acid chlorides are readily hydrolyzed under strongly acidic or strongly basic conditions, so neutral conditions would minimize hydrolysis. Most primary and secondary amines exhibit pKas of 10–11.5, so that maximal reactivity would be found at high pH and poor reactivity would be expected under neutral conditions, where the amines would be predominantly protonated. Schotten-Baumann reactions are conducted under weakly basic conditions, pH 8–10, by balancing the hydrolysis of the acid chloride with the decreased reactivity of the amine. In many cases it is wise to examine changes to a process instead of rejecting such conditions on a theoretical bias.
While optimizing a process the chemist usually learns its tolerance limits, the
ranges of process parameters at which a process will operate successfully. Knowing
these ranges is very helpful for guiding scale-up operations under suboptimal
conditions, such as overcharging or undercharging components and exposing the
reaction to temperatures above the optimal ranges.

[ Last edited by xuqinyao8239 on 2010-1-11 at 15:01 ]

回复此楼