24小时热门版块排行榜

返回列表

当前主题已经存档。

当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖

fanweihua95100

银虫 (初入文坛)

应助: 0 (幼儿园)
金币: 319.8
帖子: 31
在线: 10.8小时
虫号: 483919
注册: 2007-12-26
性别: GG
专业: 药物制剂

[交流] 【求助】跪求交联聚维酮质量标准

跪求交联聚维酮质量标准
交联聚维酮质量标准收载在USP NF1990，希望哪位大侠能帮我找到这个标准，并且找出该标准中各检测项目的具体检测方法。谢谢!非常感谢！

回复此楼

» 猜你喜欢

有没有人能给点建议已经有5人回复
假如你的研究生提出不合理要求已经有12人回复
实验室接单子已经有7人回复
全日制（定向）博士已经有5人回复
萌生出自己或许不适合搞科研的想法，现在跑or等等看？已经有4人回复
Materials Today Chemistry审稿周期已经有4人回复
参与限项已经有3人回复
对氯苯硼酸纯化已经有3人回复
所感已经有4人回复
要不要辞职读博？已经有7人回复

1楼 2009-12-30 20:12:51

已阅回复此楼关注TA 给TA发消息送TA红花 TA的回帖

fanweihua95100

银虫 (初入文坛)

应助: 0 (幼儿园)
金币: 319.8
帖子: 31
在线: 10.8小时
虫号: 483919
注册: 2007-12-26
性别: GG
专业: 药物制剂

谢谢楼上的大侠！！

回复此楼

3楼2010-01-03 20:25:20

已阅回复此楼关注TA 给TA发消息送TA红花 TA的回帖

查看全部 4 个回答

zblyyk

金虫 (小有名气)

应助: 0 (幼儿园)
金币: 1216.1
帖子: 246
在线: 54小时
虫号: 921166
注册: 2009-12-06
性别: GG
专业: 药剂学

★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★
jw227(金币+2,VIP+0):谢谢交流 12-31 10:52
fanweihua95100(金币+10,VIP+0): 1-3 20:17

我按照Crospovidone查的，具体内容自己翻译一下哈：
Crospovidone

(C6H9NO)n
1-Ethenyl-2-pyrrolidinone homopolymer.
1-Vinyl-2-pyrrolidinone homopolymer [9003-39-8].
» Crospovidone is a water-insoluble synthetic cross-linked homopolymer of N-vinyl-2-pyrrolidinone. It contains not less than 11.0 percent and not more than 12.8 percent of nitrogen (N), calculated on the anhydrous basis.
Packaging and storage— Preserve in tight containers.
USP Reference standards 11—
USP Crospovidone RS  .
鉴别 Identification—
A: Infrared Absorption 197K, on specimen previously dried in vacuum at 105 for 1 hour.
B: Suspend 1 g in 10 mL of water, add 0.1 mL of 0.1 N iodine, and shake for 30 seconds. Add 1 mL of starch TS, and shake: no blue color develops.
pH值  pH 791: between 5.0 and 8.0, in an aqueous suspension (1 in 100).
水分  Water, Method I 921: not more than 5.0%.
炽灼残渣 Residue on ignition 281: not more than 0.4%, a 2-g specimen being used.
水溶性物质 Water-soluble substances— Transfer 25.0 g of Crospovidone to a 400-mL beaker, add 200 mL of water, and stir on a magnetic stirrer, using a 5-cm stirring bar, for 1 hour. Transfer to a 250-mL volumetric flask with the aid of about 25 mL of water, add water to volume, and mix. Allow the bulk of the solids to settle. Pass about 100 mL of the relatively clear supernatant through a membrane filter having a 0.45-µm porosity, protected against clogging by superimposing a membrane filter having a 3-µm porosity. While filtering, stir the solution above the filter manually or with a mechanical stirrer, taking care not to physically damage the membrane filter. Transfer 50.0 mL of the clear filtrate to a tared 100-mL beaker, evaporate to dryness, and dry at 110 for 3 hours: the weight of the residue does not exceed 75 mg (1.50%).
重金属 Heavy metals, Method II 231: 0.001%.
乙烯基吡咯烷酮 Vinylpyrrolidinone— Suspend 4.0 g in 30 mL of water, stir for 15 minutes, centrifuge the suspension, and filter the slightly turbid upper layer through a sintered-glass, 10-µm filter. Stir the lower layer with 50 mL of water, centrifuge, and filter the upper layer through the same filter. Again stir the lower layer with 50 mL of water, and filter similarly. Add 0.5 g of sodium acetate to the combined filtrates, and titrate with 0.1 N iodine VS until the color of iodine no longer fades. Add 3.0 mL of 0.1 N iodine VS, allow to stand for 10 minutes, and titrate the excess iodine with 0.1 N sodium thiosulfate VS, adding 3 mL of starch TS as the endpoint is approached. Perform a blank determination (see Residual Titrations under Titrimetry 541), using the same total volume of the same 0.1 N iodine VS, accurately measured, as was used for titrating the specimen. Before titrating the blank, adjust with acetic acid to the same pH as that of the specimen: not more than 0.72 mL of 0.1 N iodine is consumed, corresponding to not more than 0.1% of vinylpyrrolidinone.
含氮量 Nitrogen content— Proceed as directed under Nitrogen Determination, Method II 461, using about 0.1 g, accurately weighed, of Crospovidone. In the procedure, omit the use of hydrogen peroxide, and use 5 g of a powdered mixture of potassium sulfate, cupric sulfate, and titanium dioxide (33:1:1), instead of potassium sulfate and cupric sulfate (10:1). Heat until a clear, light green solution is obtained, and heat for an additional 45 minutes; and proceed as directed for Procedure, beginning with “Cautiously add to the digestion mixture 70 mL of water.”