24小时热门版块排行榜

>论坛更新日志 (2288)
>虫友互识 (331)
>文献求助 (55)
>导师招生 (52)
>论文投稿 (32)
>休闲灌水 (27)
>博后之家 (22)
>基金申请 (21)
>考研 (15)
>招聘信息布告栏 (13)
>硕博家园 (11)
>考博 (11)
>药学 (10)
>教师之家 (9)
>找工作 (7)
>海外博后 (6)

返回列表

当前主题已经存档。

龙良平

木虫 (著名写手)

EEPI: 1
应助: 3 (幼儿园)
金币: 4893
红花: 3
帖子: 1003
在线: 304.8小时
虫号: 104916
注册: 2005-11-15
专业: 污染物行为过程及其环境效

[交流] 【求助】求助一篇被引用了近1200次的文献

Summary
Critical Reviews in Toxicology
1990, Vol. 21, No. 1, Pages 51-88 , DOI 10.3109/10408449009089873

Polychlorinated Biphenyls (PCBs), Dibenzo-p-Dioxins (PCDDs), Dibenzofurans (PCDFs), and Related Compounds: Environmental and Mechanistic Considerations Which Support the Development of Toxic Equivalency Factors (TEFs)
Stephen Safe‌

Abstract

Halogenated aromatic compounds, typified by the polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), biphenyls (PCBs), and diphenylethers (PCDEs), are industrial compounds or byproducts which have been widely identified in the environment and in chemical-waste dumpsites. Halogenated aromatics are invariably present in diverse analytes as highly complex mixtures of isomers and congeners and this complicates the hazard and risk assessment of these compounds. Several studies have confirmed the common receptor-mediated mechanism of action of toxic halogenated aromatics and this has resulted in the development of structure-activity relationships for this class of chemicals. The most toxic halogenated aromatic is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and based onin vivo andin vitro studies the relative toxicities of individual halogenated aromatics have been determined relative to TCDD (i.e., toxic equivalents). The derived toxic equivalents can be used for hazard and risk assessment of halogenated aromatic mixtures; moreover, for more complex mixtures containing congeners for which no standards are available (e.g., bromo/chloro mixtures), severalin vitro orin vivo assays can be utilized for hazard or risk assessment.
（http://informahealthcare.com/doi/abs/10.3109/10408449009089873）

回复此楼