应《网络安全法》要求，自2017年10月1日起，未进行实名认证将不得使用互联网跟帖服务。为保障您的帐号能够正常使用，请尽快对帐号进行手机号验证，感谢您的理解与支持！

24小时热门版块排行榜    

小木虫论坛-学术科研互动平台» 网络生活区» 有奖问答 » 有奖问答完结子版 » 求文献全文
81/1返回列表
查看: 384  |  回复: 7
只看楼主 @他人 存档 新回复提醒 (忽略) 收藏    在APP中查看
当前主题已经存档。

yao7601

禁言 (正式写手)
本帖内容被屏蔽

» 猜你喜欢
1楼 2009-12-24 21:54:20
已阅   关注TA 给TA发消息 送TA红花 TA的回帖

caijj09

木虫 (职业作家)
这篇文章好像没找到，至少我们学校的数据库里没找到
赞一下 回复此楼
自强不息
2楼2009-12-24 22:44:50
已阅   关注TA 给TA发消息 送TA红花 TA的回帖

caijj09

木虫 (职业作家)
不好意思哈！圣诞快乐！
赞一下 回复此楼
自强不息
3楼2009-12-24 22:45:07
已阅   关注TA 给TA发消息 送TA红花 TA的回帖

yao7601

禁言 (正式写手)
本帖内容被屏蔽
4楼2009-12-24 22:56:34
已阅   关注TA 给TA发消息 送TA红花 TA的回帖

大唐必盛

禁言 (小有名气)
本帖内容被屏蔽
5楼2009-12-25 08:52:15
已阅   关注TA 给TA发消息 送TA红花 TA的回帖

yao7601

禁言 (正式写手)
本帖内容被屏蔽
6楼2009-12-25 12:32:51
已阅   关注TA 给TA发消息 送TA红花 TA的回帖

hdongming

木虫 (小有名气)
Abstract
Sustained-release approaches are emerging for the delivery of drugs from polymer encapsulation. However, the most persistent problem that remains is the initial burst release of the drug, which can exceed the toxic limits. Dexamethasone, a hydrophobic drug, was encapsulated in poly(lactide-co-glycolide) (PLGA) microparticles using the solvent evaporation method. The drug release profile of these microparticles was studied and the initial burst was reduced by crosslinking of the microparticle surface using ethylene glycol dimethacrylate and tri(ethylene glycol) dimethacrylate. Due to surface crosslinking, an additional diffusional resistance was created, which prevented easy dissolution of the drug into the release medium and brought about a substantial reduction in the initial burst release. Moreover, the time required for reaching a stationary-state release was also observed to be delayed, prolonging the sustained drug delivery. This concept was further tested with a hydrophilic drug, the sodium salt of dexamethasone phosphate, encapsulated in PLGA polymer microparticles and was observed to reduce the burst release as well. For synthesizing the polymer microparticles containing dexamethasone, an o/w microemulsion and solvent evaporation technique was used; whereas, for those containing dexamethasone phosphate, w/o/o/o phase separation/coacervation technique was used. The surface crosslinking was performed by ultraviolet radiation.  
Keywords: Dexamethasone; Dexamethasone phosphate; PLGA; Controlled drug release; Sustained release formulations; EGDMA; Tri(EG)DMA; UV surface crosslinking; HPLC  
不好意思 只查到摘要
赞一下 回复此楼
7楼2009-12-25 16:43:58
已阅   关注TA 给TA发消息 送TA红花 TA的回帖

chentiegang

木虫 (正式写手)
★ ★ ★
xjxlovelxl(金币+3,VIP+0): 12-25 18:41
http://d.namipan.com/d/20bf8fe44 ... 1f1416304f76daf1300
赞一下(10人) 回复此楼
站在茶几边缘
8楼2009-12-25 17:20:17
已阅   关注TA 给TA发消息 送TA红花 TA的回帖
相关版块跳转 我要订阅楼主 yao7601 的主题更新
81/1返回列表
最具人气热帖推荐 [查看全部] 作者 回/看 最后发表
[基金申请] 能否申诉？ +4 echo8914667 2026-08-30 5/250 2026-08-30 21:11 by echo8914667
[基金申请] 为什么到现在没收到通知？ +5 tannykie 2026-08-29 5/250 2026-08-30 21:05 by purplejack
[基金申请] 有没有仍没收到信息的 +7 德尚中行 2026-08-27 8/400 2026-08-30 20:52 by purplejack
[考博] 找导师 +6 yuanjiabao 2026-08-29 7/350 2026-08-30 14:40 by 生科新手
[基金申请] 29号明天会评吗 +3 笨笨唐 2026-08-28 3/150 2026-08-30 09:29 by cww8181
[基金申请] 国自然面上复盘~欢迎讨论 (金币+15) +15 晴天加油 2026-08-26 16/800 2026-08-29 18:28 by symmetry
[基金申请] 2026年叶企孙基金 +4 bud_bud 2026-08-27 7/350 2026-08-29 07:23 by foolishmani
[基金申请] 为什么资助数各大高校都创新高，自己申请怎么就这么难 +12 Kittylucky 2026-08-27 13/650 2026-08-29 00:04 by superceng
[基金申请] 基金系统什么内容也没有 30+4 winsaint 2026-08-27 9/450 2026-08-28 11:06 by maolC
[基金申请] 怎么查啊 +6 huang1991js 2026-08-26 6/300 2026-08-28 08:42 by winsaint
[基金申请] 哪位高人中了，把查询到的截图贴出来让我看看，让我长长见识 +5 yuleib84 2026-08-26 6/300 2026-08-28 00:02 by yudaoqian88
[基金申请] 面上合作单位盖章 +5 ssyjh 2026-08-27 5/250 2026-08-27 20:50 by gdfollow
[文学芳草园] 梦想 +3 myrtle 2026-08-26 3/150 2026-08-27 10:01 by angelyueyi
[基金申请] 我不理解！ +15 Edward_pc 2026-08-26 23/1150 2026-08-26 20:34 by zzuzxg
[基金申请] 能否退出参与的面上项目解除限项 +23 koalala 2026-08-24 26/1300 2026-08-26 14:29 by 宝贝虫子
[基金申请] 系统进不去 +4 yanglien 2026-08-26 5/250 2026-08-26 11:10 by wenfengw83
[基金申请] 国合可查了 +3 paperzjh 2026-08-26 3/150 2026-08-26 10:41 by LemmonTr
[基金申请] 国合现在查不到了吗？ +10 chengyan1220 2026-08-24 20/1000 2026-08-26 08:57 by peasantsprig
[基金申请] 牛来！米来！面来！ +8 beefly 2026-08-26 8/400 2026-08-26 08:37 by xuzhipiao
[基金申请] 没有任何消息-是不是就凉了 +9 图啦图啦 2026-08-24 10/500 2026-08-25 11:59 by 南海小哥
信息提示
关闭
请填处理意见
关闭