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zap65535木虫 (著名写手)
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The major pet food recall associated with acute renal failure in dogs and cats focused initially on melamine as the suspect toxicant. In the course of the investigation, cyanuric acid was identified in addition to melamine in the offending food. The purpose of this study was to characterize the toxicity potential of melamine, cyanuric acid, and a combination of melamine and cyanuric acid in cats. In this pilot study,melamine was added to the diet of 2 cats at 0.5% and 1%, respectively. Cyanuric acid was added to the diet of 1 cat at increasing doses of 0.2%, 0.5%, and 1% over the course of 10 days. Melamine and cyanuric acid were administered together at 0%, 0.2%, 0.5%, and 1% to 1 cat per dose group. No effect on renal function was observed in cats fed with melamine or cyanuric acid alone. Cats dosed with a combination were euthanized at 48 hours after dosing because of acute renal failure. Urine and touch impressions of kidneys from all cats dosed with the combination revealed the presence of fan-shaped, birefringent crystals. Histopathologic findings were limited to the kidneys and included crystals primarily within tubules of the distal nephron, severe renal interstitial edema, and hemorrhage at the corticomedullary junction. The kidneys contained estimated melamine concentrations of 496 to 734 mg/kg wet weight and estimated cyanuric acid concentrations of 487 to 690 mg/kg wet weight. The results demonstrate that the combination of melamine and cyanuric acid is responsible for acute renal failure in cats. |
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zap65535
木虫 (著名写手)
两院大学士后
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2楼2009-12-11 15:06:55
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zap65535(金币+30,VIP+0):速度，等我再挣5金币，就给你加上 12-11 17:01
zap65535(金币+30,VIP+0):速度，等我再挣5金币，就给你加上 12-11 17:01
| 因引起狗，猫的急性肾衰竭而导致的宠物食品大召回起初主要聚焦在疑似有毒物三聚氰胺上。在调查过程中发现，有毒食品中除了三聚氰胺外，还含有氰尿酸。本研究的目的就是探明三聚氰胺，氰尿酸或两者共同作用对猫的毒性潜能。在这项新的研究中，两只猫的日粮中分别加入浓度为0.5%和1%的三聚氰胺。另外一只猫在10天的研究过程中，其日粮中加入氰尿酸，浓度逐步提高，从0.2%到0.5%，再到1%。然后，用三聚氰胺和氰尿酸共同饲喂，每剂量组中一只猫饲喂的剂量分别为0%,0.2%,0.5%和1%。单独饲喂三聚氰胺或氰尿酸不影响猫的肾功能。因为急性肾衰竭，饲喂48小时后，对饲喂两种物质的猫实施安乐死。从饲喂两种物质猫的尿液和对猫肾的触感能够发现有呈扇形的双折射的晶体形成。仅限于组织病理学的分析发现，这些晶体主要集中在远端肾单位的小管中，皮质髓质结合处存在严重的肾间质水肿，出血。肾脏中含有三聚氰胺的浓度大约为496－734mg/kg·体重，氰尿酸的浓度大约为487－690mg/kg·体重。结果证明共同饲喂三聚氰胺和氰尿酸能引起猫的急性肾衰竭。 |
3楼2009-12-11 17:00:34
zap65535
木虫 (著名写手)
两院大学士后
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- 虫号: 704450
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- 专业: 马克思主义思想史
4楼2009-12-11 21:00:32
