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yexuqing木虫之王 (文学泰斗)
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【其他】转帖 酸鹼應答型高分子微胞藥物傳輸系統
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???|????????????????????y 2009/11/27 [ [url= ocPrint(8202)]?? ?? ?? ?[/url] | ?? ?] ?? ?? ]????????(Polymeric Micelle)??????к??????(Core-shell)?ΑB????????D????????????????(Amphiphilic Copolymer)?????W????????????О????????y????????????????M?b(Selfassembly)?γ????????????????????????Y?????????????Ч?????????????????????????????????I????O???????????????У??????????????????d?w(Drug Carrier)??????????????????????^???????????????????????y??????????????????????????????????????a???O?????????W?????????????f?????????????Ч??????????????h??e??[???M??????K?_???????[??????????????N??????????g?u?u???F???t?W???????????????????M??Ч???p??????á??????????????????????????????S???^?L???Ч?r??????u???????????????????????????????????????????????γ?????????????????????z????  ?D??????????B????????? ????F朹????????????b?d?c??? ??????????M????????????????(Amphiphilic)?????朶????M????D???????????????H?朶?(Hydrophilic Chain)???????t?????H??朶?(Hydrophobic Chain)???????????????????????????^?R????????r???????????????????朶Ε???^?????????(Van Der Waal Force)??????????Y???γ????????????H????????????????????Y??????H??朶Σ????(Layer)???H?朶λ????Y???? ?????????F朹?????(Amphiphilic Block Copolymers)???V???\????u??W?I??????B?m???????á????????????c????????????????(Multidrug Resistance)??l????????????d?w???O?????档?о??l?F??????F朹????????????????????????h???У??_???R????????(CMC)?r??????F朹???????γ???к???Y??(Core-shell Structure)???????????????????????????γ????????????????????????÷????????? ??????????????d?w????? ????????????d????????_???_???????M????????????????M??????????????@Щ?????d?w???_?????簩????????????????g????K??????g????????????l?d?w?ΑB???????M????????????????????M???_???????(Target)???f?c????Ч????????????????????????w??h???????????????????????????????pH ??????|??????????????????????a???????????????????_???????[???????????? ?C??????????????????????????y?????c???????????о????^?L??????(Half-life)???????L????e?????w??????????d?w????????c?Y????????????????????c?????|?????????????????????ж?N?x?????????????|?? ???|????????? ???|????????????????h?????????|??????a???????????@????????п???x????F????h??pH ????????????????Y???????????????|?????????????????????u?????????в????о??????ü???????pH ????????M???^???pH ????????O?????Y???K????????_?????c?????????? ???|???????????????h?????????????N?????????N????M?b???γ?????????????п???x????F??????h??????ò???????????????Y????????N?t?????????????е???W?I?I?Y????????????????????h?????????????? 1. Pullulan Acetate/Oligomeric Sulfadimethoxoine You Han Bae ????F?l????????|??Pullulan Acetate (PA) ???D?壩?????????????朶????????B??Oligomeric Sulfadimethoxine (OSDM)????pH = 7.4 ?????????γ????С??50~60nm??????????h????pH ??????7.2~6.8 ?r?? OSDM ???????x??????????????????????s??????????B???????????????pH ??????6.8~6.2 ?r????24 С?r??????Ч???????????????????????Doxorubicin(DOX)???????  ?D????Poly(L-histidine-co-L-phenylalanine) 3. ????????????W?I??????I?Y?????????Y???? ??N?????|???????W?I?^???????Hydrazone Bond??Acetal Bond??N-link Imidazole????????@Щ???W?I??????I?Y?????????????Y??????D??????γ?????????????f??y??????????????????????鼚??????Щ?????h???^????Endosome (pH = 5.0~6.0)??Lysosome (pH =4.0~5.0)?????????????е???W?I?I?Y??????????????????????W?I???????????????????M???_????K??Ч??????????????? ??????????M????????????|??????????????/?????????? ????????????I?????s?I275??????????Y??????http://www.materialsnet.com.tw/DocView.aspx?id=8167 [ Last edited by yexuqing on 2009-11-27 at 11:08 ] |
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