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ÄãÓ¦¸ÃÈ¥ÎÄÏ×ÇóÖúÇø~ Literature References: DNA topoisomerase I inhibitor. Semisynthetic derivative of camptothecin, q.v.; de-esterified in vivo to the active metabolite, 7-ethyl-10-hydroxycamptothecin (SN-38). Prepn: JP Kokai 85 19790; T. Miyasaka et al., US 4604463 (1985, 1986 both to Yakult Honsha); S. Sawada et al., Chem. Pharm. Bull. 39, 1446 (1991). Antitumor activity and toxicity data: T. Kunimoto et al., Cancer Res. 47, 5944 (1987). Mechanism of action study: Y. Kawato et al., ibid. 51, 4187 (1991). Clinical trial in colorectal cancer: J. Y. Douillard et al., Lancet 355, 1041 (2000). Review of pharmacology and clinical experience: N. Masuda et al., Crit. Rev. Oncol. Hematol. 24, 3-26 (1996); S. O'Reilly, E. K. Rowinsky, ibid. 47-70. |
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