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[交流] 美国弗吉尼亚大学Yang Lab招收Research Scientist, 博后、博士生、技术员、访问学者

研究简介Research Overview:
The Yang Lab is focused on studying the molecular mechanisms of cellular stress response pathways. We use an interdisciplinary approach, integrating structural biology (Cryo-EM), computational biology (de novo protein design) biochemistry (protein characterization), and cell biology (fluorescent imaging). Our goal is to modulate those stress response pathways in physiological and pathological conditions, potentially leading to the development of novel therapeutics for related human diseases, including neurodegeneration, metabolic disorders, and cancer. In addition, we have established close collaborations with experts in disease-relevant mouse models to complement our mechanistic findings.

期望的候选人Expected Candidates:
We are seeking highly motivated, talented researchers to join our interdisciplinary research team. Our laboratory integrates structural biology, membrane protein biophysics, protein engineering, computational protein design, and drug discovery to address challenging questions in biology and develop innovative therapeutic strategies.
We welcome candidates with strong training and research experience in one or more of the following areas:

• Cryo-Electron Microscopy
Experience with cryo-EM sample preparation, grid optimization, data collection, image processing, and structural analysis.
• Membrane Protein Biology
Experience in the expression, purification, stabilization, and biochemical/biophysical characterization of membrane proteins.
• Cell Culture and Cellular Biology
Hands on experience with mammalian cell culture, transfection, protein expression, cellular assays, or fluorescence-base assays.
• Insect Cell Expression
Experience with insect cell culture and recombinant protein expression, particularly using the baculovirus expression system.
• X-ray Crystallography
Experience with protein crystallization, crystal optimization, C-ray diffraction data collection, structure determination, refinement, and model building.

学校简介The University of Virginia:
Recognized as one of the top universities in the US, the University of Virginia is known as a member of the "Public Ivy" and one of the 25 members of the "New Ivy League." The university consistently ranks among the top 30 best universities in the United States, holding the 24th position in the 2024 U.S.

申请方式How to Apply: Please email a cover letter and CV to Dr. Yang at wfw7nc@virginia.edu.

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