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多功能离子响应性自组装肽-聚合物/MXene复合水凝胶及其在糖尿病创面修复中的应用
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项目编号 SFXJTU2623 Brief introduction of the three supervisors (e.g. key academic background, work experience, research area, etc.) 三校导师简介，包括但不限于学术背景、工作经历及研究领域等 Dr. Huifeng Wang is an Assistant Professor in the Department of Chemistry and Materials Science at Xi'an Jiaotong-Liverpool University (XJTLU). She obtained her PhD in Chemical Engineering from the University of Illinois and completed postdoctoral training at Northwestern University. Her research focuses on biomaterials, tissue engineering, and regenerative medicine, with particular interests in multifunctional hydrogels, bioactive polymers, and biomaterial-mediated microenvironment regulation for tissue regeneration and diabetic wound healing. Dr. Yi Lin is an Associate Professor in the Department of Chemistry and Materials Science at Xi'an Jiaotong-Liverpool University (XJTLU). She obtained her PhD in Organic Chemistry from Claude Bernard University Lyon 1 (France), where her research focused on the synthesis of calixarene-based supramolecular systems. Before joining XJTLU, she served as Assistant Director of the R&D Center at Xiamen Bioway Biotech Co., Ltd. from 2011 to 2013. Her current research interests focus on the design, synthesis, and characterization of novel organic semiconductor materials for advanced electronic and optoelectronic applications. Dr. Yu Zhou is an Associate Professor and PhD Supervisor in the School of Chemistry at Xi'an Jiaotong University (XJTU). He received his PhD from the University of Groningen, the Netherlands, and completed postdoctoral training at Aalto University, Finland. His research focuses on biohybrid materials constructed from biological macromolecules, with particular expertise in protein-based biomaterials for biomedical applications. In this project, he will contribute complementary expertise in advanced biomaterials design, recombinant protein engineering, and nanomaterial integration, supporting the development and optimization of the peptide–polymer/MXene hybrid hydrogel system. Dr. William Sharratt is a Lecturer in Soft Matter at the University of Liverpool and leads the Soft Materials Group within the School of Engineering. He obtained his PhD in Chemical Engineering from Imperial College London and previously held an EPSRC Doctoral Prize Fellowship. His research focuses on the design and characterization of functional soft materials, including polymers, surfactants, and colloids, using advanced scattering, microscopy, and microfluidic techniques. In this project, he will provide expertise in soft material characterization, self-assembly, and structure–property relationships, supporting the development and optimization of the peptide–polymer/MXene hybrid hydrogel system. 王汇丰博士现任西交利物浦大学化学与材料科学系助理教授。她于美国伊利诺伊大学获得化学工程博士学位，并于美国西北大学完成博士后研究。其研究方向主要包括生物材料、组织工程与再生医学，重点关注多功能水凝胶、生物活性高分子材料，以及基于生物材料调控组织微环境促进组织再生和糖尿病创面愈合。 林昳博士现任西交利物浦大学化学与材料科学系副教授。她于法国里昂第一大学获得有机化学博士学位，博士期间主要从事基于杯芳烃的超分子体系设计与合成研究。2011年至2013年，她担任厦门百维生物科技有限公司研发中心副主任，负责相关研发工作。其当前研究方向主要聚焦于新型有机半导体材料的设计、合成与性能表征，并致力于其在先进电子与光电子器件中的应用。 周雨博士现任西安交通大学化学学院副教授、博士生导师。他于荷兰格罗宁根大学获得博士学位，并在芬兰阿尔托大学完成博士后研究。其研究方向聚焦于以生物大分子为构筑单元的生物杂化材料，尤其在蛋白质基生物材料及其生物医学应用方面具有丰富经验。在本项目中，他将发挥在先进生物材料设计、重组蛋白工程及纳米材料集成方面的专长，为肽–聚合物/MXene杂化水凝胶体系的设计、构建与优化提供重要支持。 William Sharratt 博士现任英国利物浦大学工程学院软物质方向讲师，并担任软材料研究团队负责人。他于英国帝国理工学院获得化学工程博士学位，并曾获英国工程与物理科学研究委员会（EPSRC）博士奖学金。其研究聚焦于功能软材料（包括聚合物、表面活性剂和胶体）的设计与表征，擅长利用散射技术、显微技术及微流控等先进方法研究材料的自组装行为及结构–性能关系。在本项目中，他将为肽–聚合物/MXene杂化水凝胶体系的设计优化及软材料表征提供专业指导。 Key aspect/summary of your research project 项目简介 Chronic diabetic wounds represent a major healthcare challenge due to persistent inflammation, excessive oxidative stress, bacterial infection, impaired angiogenesis, and delayed tissue regeneration. Existing wound dressings primarily provide passive protection and often fail to actively regulate the pathological wound microenvironment. Therefore, there is an urgent need to develop multifunctional biomaterials capable of promoting tissue repair through coordinated biological regulation. This project aims to develop a multifunctional ion-responsive self-assembled peptide–polymer/MXene hybrid hydrogel as a next-generation therapeutic platform for diabetic wound healing. By integrating bioactive self-assembling peptides, functional polymers, MXene nanomaterials, and ion-responsive crosslinking strategies, the hydrogel will be engineered to mimic key features of the native extracellular matrix while providing tunable mechanical properties, excellent injectability, and sustained bioactivity. The multifunctional hydrogel is expected to dynamically regulate the wound microenvironment by scavenging reactive oxygen species, modulating immune responses, promoting angiogenesis, inhibiting bacterial infection, and accelerating tissue regeneration. The project combines expertise in biomaterials engineering, protein engineering, nanomaterials, and regenerative medicine. The successful candidate will undertake the rational design, synthesis, and physicochemical characterization of the hydrogel, followed by comprehensive biological evaluation using in vitro cell models and diabetic wound animal models. This interdisciplinary research will provide fundamental insights into the design of bioactive hybrid biomaterials and contribute to the development of innovative therapeutic strategies for chronic wound management, with strong potential for future clinical translation. 糖尿病慢性创面由于持续炎症、过量活性氧（ROS）积累、细菌感染、血管新生不足及组织再生能力受损，已成为临床治疗中的重大挑战。现有创面敷料主要提供物理保护，难以主动调控复杂的创面微环境，因此，开发兼具多种生物活性的智能生物材料对于促进糖尿病创面修复具有重要意义。 本项目拟构建一种多功能离子响应性自组装肽–聚合物/MXene复合水凝胶，用于糖尿病创面的精准治疗。该体系将融合生物活性自组装肽、功能聚合物、MXene二维纳米材料及离子响应性交联策略，构建具有细胞外基质（ECM）仿生结构和优异理化性能的多功能水凝胶。通过合理设计材料组成与结构，实现对创面微环境的动态调控，赋予材料抗氧化、免疫调节、促血管新生、抗菌及促进组织再生等多重功能，从而加速糖尿病创面的修复过程。 本项目将结合生物材料设计、蛋白质工程、纳米材料及再生医学等多学科优势，系统开展杂化水凝胶的构建与优化、理化性能表征、生物学功能评价及糖尿病创面修复机制研究。研究成果不仅有望揭示多功能杂化生物材料调控创面微环境的新机制，也将为新一代智能创面修复材料的设计与临床转化提供理论基础和技术支撑。 Other preferred qualification and skill set of the candidate 对项目候选人的其他学术背景及技能要求 Preference will be given to candidates with prior research experience in one or more of the following areas: biomaterials, hydrogels, polymers, peptide or protein engineering, nanomaterials, tissue engineering, or regenerative medicine. Experience in materials characterization (e.g., SEM, FTIR, XRD, rheology, or mechanical testing), cell culture, molecular biology, or animal studies is advantageous. Candidates with strong problem-solving skills, scientific writing ability, and experience in interdisciplinary research are encouraged to apply. 具有以下一个或多个研究方向经验者将优先考虑：生物材料、水凝胶、高分子材料、肽/蛋白质工程、纳米材料、组织工程或再生医学。具有材料表征（如SEM、FTIR、XRD、流变学或力学性能测试）、细胞培养、分子生物学实验或动物实验经验者优先。申请人应具备良好的科研创新能力、独立思考与解决问题能力，以及较好的英文文献阅读和学术写作能力，具有跨学科研究经历者将更具竞争力。 有意者请将个人简历及其他有助于申请的材料发送至 Huifeng.Wang@xjtlu.edu.cn 注: 不用跟帖，直接发邮件就行，主题请注明博士申请。 |
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2026-09-02 10:27:04, 164.67 K
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