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西交利物浦大学-西安交通大学-英国利物浦大学博士联合培养项目招生
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项目课题： 基于多价DNA介导识别的蛋白质聚集体电化学生物传感 Electrochemical Biosensing of Protein Aggregates Using Multivalent DNA-Mediated Recognition 导师简介： 徐培程，西交利物浦大学慧湖药学院助理教授，剑桥大学物理学博士，研究聚焦DNA纳米技术与液晶辅助智能传感器件，具备胶体自组装与仿生纳米材料的扎实实验基础。刘必武博士，西安交通大学教授、博导，国家海外优青，滑铁卢大学博士及博士后，师从Juewen Liu教授，长期致力于功能核酸材料、智能生物传感及冷冻驱动生物界面构建，以第一/通讯作者在JACS、Angew. 等期刊发表多篇高水平论文。陈碧琼教授，利物浦大学软物质化学讲席教授，曾任贝尔法斯特女王大学高分子工程教授，研究涵盖智能可持续高分子、多功能纳米复合材料及仿生结构，强调材料全生命周期设计，并推动其在医疗、能源与软体机器人等领域的应用转化。 Dr. Peicheng Xu is an Assistant Professor at the XJTLU Wisdom Lake Academy of Pharmacy. He holds a Ph.D. in Physics from the University of Cambridge, and his research focuses on DNA nanotechnology and liquid crystal–enabled intelligent sensing devices, with strong experimental expertise in colloidal self-assembly and bio-inspired nanomaterials. Dr. Biwu Liu is a Professor and Doctoral Supervisor at Xi’an Jiaotong University, and a recipient of China’s National Overseas Excellent Young Scientist Award. He completed his Ph.D. and postdoctoral training at the University of Waterloo under the supervision of Prof. Juewen Liu. His research centers on functional nucleic acid materials, intelligent biosensing, and cryo-driven bio-interface engineering, with over 30 first-/corresponding-author publications in high-impact journals including J. Am. Chem. Soc. and Angew. Chem. Int. Ed. Prof. Biqiong Chen holds the Chair in Soft Matter Chemistry at the University of Liverpool’s Department of Chemistry. Prior to this, she served as Professor of Polymer Engineering at Queen’s University Belfast. Her research encompasses smart sustainable polymers, multifunctional polymer nanocomposites, and biomimetic structures, emphasizing a holistic, lifecycle-oriented approach—from molecular design and synthesis to processing, application, and end-of-life strategies—and translating these materials for use in healthcare, energy, soft robotics, and beyond. 项目简介： 蛋白质聚集体是神经退行性疾病中的关键生物标志物，然而其异质性组装结构使得针对特定聚集态（如单体、低聚体与纤维）的精准识别面临巨大挑战。为此，我们拟构建一种集成式电化学生物传感平台，以实现对复杂样本中单体、低聚体及纤维等不同聚集态的高分辨检测。该平台将通过可编程的三维DNA纳米结构，以纳米级精度精确排布多价识别探针，从而实现几何构型匹配、协同增强的特异性识别。同时，我们将耦合水相两相分离技术，在维持聚集体天然构象的前提下对其进行富集，并系统量化富集动力学与选择性。此外，拟构建一种具有分级多孔结构的电化学传感界面，以协同提升有效比表面积、物质传质效率与信号密度；并辅以局域化核酸扩增策略，在无需复杂前处理的前提下显著增强检测信号。综上，通过三维DNA识别模块、多价富集策略与工程化信号转导界面的协同整合，本平台有望在临床相关浓度范围内实现对蛋白质聚集体的高灵敏、高选择性与快速检测。 Protein aggregates are critical biomarkers in neurodegenerative diseases, yet heterogeneous assembly complicates state‑specific detection. We propose an integrated electrochemical biosensing platform to resolve monomers, oligomers, and fibrils in complex samples. Programmable 3D DNA architectures will be assembled to position polyvalent probes with nanometer precision, enabling geometry‑matched, cooperative recognition. Aqueous two‑phase separation will be coupled to enrich aggregates while preserving native states, and enrichment kinetics and selectivity will be quantified. A hierarchically porous electrochemical interface will be engineered to increase effective surface area, mass transport, and signal density, while localized nucleic acid amplification will elevate responses without extensive preprocessing. Together, DNA 3D recognition, multivalent enrichment, and engineered transduction will deliver sensitive, selective, and rapid readouts at clinically relevant concentrations. |
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2026-08-27 16:42:05, 244.87 K
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