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中国海洋大学王杨教授课题组招收“申请-考核”制博士研究生
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一、导师介绍 王杨，教授，博士生导师。2008年本科毕业于中国农业大学，同年保送至北京大学化学与分子工程学院，2013年在北京大学获得有机化学博士学位（导师：席振峰院士，张文雄教授）。之后获得欧盟“玛丽居里”学者计划，在瑞士洛桑联邦理工学院（EPFL）从事博士后研究（导师：Jieping Zhu教授）。2017年至2019年在加拿大西蒙弗雷泽大学（SFU）从事博士后研究（导师：Robert Britton教授）。2019年加入中国海洋大学医药学院独立开展研究工作。2020年入选山东省泰山学者青年专家。在有机化学、药物化学领域具有丰富的经验。近年来在Science, Chem. Soc. Rev., Nat. Commun., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Chin. Chem. Lett., JACS Au, Green Chem., Green Synth. Catal., Chin. J. Chem., Org. Lett., Org. Chem. Front.等期刊发表SCI收录论文几十多篇。获得授权专利6项。主持国家级、省部级基金项目多项，担任 国际期刊的审稿人。 研究方向：有机合成方法学、药物合成 已发表论文： 1. Tengfei Xuan, Hongwei Zhao, Yichi Zhang, Jinyu Wang, Shuang Yang, Wei Wang,* and Yang Wang.* Asymmetric Catalytic Construction of 1,1-Diheteroquaternary Tetrahydro-β-carbolines Enables Collective Syntheses of Polycyclic Alkaloids. J. Am. Chem. Soc. 2026, 148, 879. 2. Xiaochen Tian, Hongli Wu, Yaoyu Shi, Xiaonan Cui, Ruochen Pang, Boqi Zhang, Rongrong Zhou, Ling Lu,* Yun-Fang Yang,* and Yang Wang.* Switchable Reactivity of Hydrazonoyl Halides: Enabling the Discovery of Potent Hypoxia-Inducible Factor Inhibitors. JACS Au 2026, 6, 3164. 3. Pengcheng Shaoa, Hang Chenga, Yanting Lia, and Yang Wang.* Asymmetric catalytic construction of β-carbolines via nucleophilic addition of silyl enol ethers with cyclic imines. Chin. Chem. Lett. 2026, DOI: https://doi.org/10.1016/j.cclet.2026.112795. 4. Yidong Huang, HongLi Wu, Yuxin Tian, Lesong Li, Yun-Fang Yang,* and Yang Wang.* Asymmetric [1+4] Cyclization of α-Chloro Hydrazones for the Synthesis of Pyrazoline-spirooxindoles. Chin. J. Chem. 2026, 44, 1783. 5. Pengcheng Shao, Hang Cheng, and Yang Wang.* Asymmetric Catalytic Dual-Site Functionalization of Allyl Bromides: Construction of Diverse Heterocyclic Frameworks. Chin. J. Chem. 2026, 44, 111. 6. Changhong Han, Hongli Wu, Tao Liu, Yun-Fang Yang,* and Yang Wang.* Regioselective α‑Addition of Deconjugated γ‑Butenolides: Synthesis of Functionalized Dihydroquinolinones. Org. Lett. 2026, 28, 3371. (Cover Page) 7. Changhong Han, Xiaochen Tian, Hang Cheng, Yanting Li, Tao Liu, and Yang Wang.* Copper-Catalyzed Umpolung Strategy of N -2,2,2-Trifluoroethylisa-tin Ketimines for the Synthesis of Spirobenzodiazepine Oxindoles. Chem. Eur. J. 2026, 32, e00001. 8. Yaoyu Shi, Yongxing Zhang, Xiang Xu, Yanting Li, Jingze Chen, and Yang Wang.* Asymmetric Synthesis of 2,3-Dihydrooxazoles via Acylaziridine Rearrangement of 2‑(1-Tosylalkyl)naphthols with N,O‑Hydroxylamines. J. Org. Chem. 2026, 91, 10307. 9. Yongxing Zhang, Xiaochen Tian, and Yang Wang.* Asymmetric Catalytic [3+3] Annulations of Unmodified Morita-Baylis-Hillman Alcohols to Construct Diverse Heterobicyclic [4.3.0] Skeletons. JACS Au, 2025, 5, 5039. 10. Tengfei Xuan, Yuan Pan, Zhenyu Shi, and Yang Wang.* Organocatalytic asymmetric synthesis of oxazolines from N-acylimines. Chin. Chem. Lett. 2025, 36, 110352. 11. Tingting Zhang, Xiaochen Tian, Xin Shu, Honghan Li, Yihan Lu, and Yang Wang.* Indolylmethanols as C4 synthons for the asymmetric synthesis of indole-fused spiro compounds. Chin. J. Chem. 2025, 43, 3483. 12. Tengfei Xuan, Xia Wang, and Yang Wang.* Asymmetric [3+2] cycloannulation of benzoxazinones for the synthesis of imidazo[5,1‑c]oxazinones. Org. Lett. 2025, 27, 3134. 13. Xin Shu, Tingting Zhang, Yongxing Zhang, Kexin Tong, Shumin Wang, and Yang Wang.* Asymmetric construction of enantioenriched spiro gem-diamines via [3+3] annulation of α,β-unsaturated N-sulfonyl ketimines and 3-aminobenzofurans. Org. Chem. Front. 2025, 12, 3643. 14. Xiaochen Tian, Tengfei Xuan, Jingkun Gao, Xinyu Zhang, Tao Liu, Fengbiao Luo, Ruochen Pang, Pengcheng Shao, Yun-Fang Yang,* and Yang Wang.* Catalytic enantioselective nitrone cycloadditions enabling collective syntheses of indole alkaloids. Nat. Commun. 2024, 15, 6429. 15. Lesong Li, Tao Liu, Weiwu Ren, and Yang Wang.* Catalyst-free and atom-economical [4+3] cycloaddition of azadienes with cyclic azomethine imines for facile synthesis of 1,2,4-triazepines. Green Synth. Catal. 2024, 5, 57. 16. Shuting Zhang, Xinyu Zhang, Lesong Li, Zhenyu Shi, and Yang Wang.* Synthesis of pyridazino[4,5-b]indoles by [3+3] annulation of 2-alkenylindoles and hydrazonyl chlorides. Chem. Eur. J. 2024, 30, e202400278. 17. Lesong Li, Congyang Li, Shuting Zhang, Xuerui Wang, Peng Fu, and Yang Wang.* Catalytic asymmetric synthesis of 3,4′-piperidinoyl spirooxindoles via [3+3] annulation of 3‑aminobenzofurans and isatin-derived enals. J. Org. Chem. 2024, 89, 5170. 18. Lesong Li, Xia Wang, and Yang Wang.* Construction of spiro[pyrrolidine-azlactone] via [2+3] cycloaddition of alkylidene azlactone with trifluoromethylated imine J. Org. Chem. 2024, 89, 17824. 19. Xinyu Zhang, Yuan Pan, Tao Liu, and Yang Wang.* Synthesis of 4‑aryl-1,3,4-benzotriazepinones from isatoic anhydrides and hydrazonyl chlorides. J. Org. Chem. 2023, 88, 7504. 20. Hao Dong, Yongxing Zhang, Xiaochen Tian, Ruochen Pang, Weiwu Ren, and Yang Wang.* Catalyst-free and oxidant-free tandem aza-Mannich/cyclization/aromatization of C,N-cyclic azomethine imines with enamides: facile synthesis of 5,6-dihydropyrazolo[5,1-a]isoquinolines. Green. Chem. 2022, 24, 5508. (Cover Page) 21. Lesong Li, Tao Liu, Xiaoli Zhang, Xiaohan Hou, Hao Dong, Xiaoyang Li, Weiwu Ren, and Yang Wang.* Catalyst-free and atom-economical 1,3-dipolar cycloaddition of C,N-cyclic azomethine imines: facile synthesis of isoquinoline-fused spirocycles. Green Synth. Catal. 2022, 2, 69. 22. Fengbiao Luo, Hao Dong, Weiwu Ren, and Yang Wang.* Organocatalytic asymmetric synthesis of tetrahydroquinolines from ortho-aminophenyl para-quinone methides. Org. Lett. 2022, 24, 7727. 23. Yuan Pan, Weiwu Ren, Zhanhao Zhang, Fengbiao Luo, Xiaohan Hou, Xiaoyang Li, Yun-Fang Yang,* and Yang Wang.* Tandem 1,6-addition/cyclopropanation/rearrangement reaction of vinylogous para-quinone methides with 3-chlorooxindoles: construction of vicinal quaternary carbon centers. Org. Chem. Front. 2022, 9, 3697. 24. Xiaochen Tian, Yongxing Zhang, Hao Dong, Weiwu Ren, and Yang Wang.* Asymmetric α‑regioselective [3+2] annulation of Morita−Baylis−Hillman carbonates: construction of three contiguous stereocenters with vicinal quaternary carbon centers. J. Org. Chem. 2022, 87, 9593. 25. Xiaochen Tian, Yongxing Zhang, Weiwu Ren, and Yang Wang.* Synthesis of functionalized 3,2'-pyrrolidinyl spirooxindoles via domino 1,6-addition/annulation reactions of para-quinone methides and 3-chlorooxindoles. Org. Chem. Front. 2022, 9, 615. (Cover Page) 26. Michael Meanwell, Steven M. Silverman, Johannes Lehmann, Bharanishashank Adluri, Yang Wang, Ryan Cohen, Louis-Charles Campeau, Robert Britton.* A short de novo synthesis of nucleoside analogs. Science 2020, 369, 725. 27. Yang Wang,* Wen-Xiong Zhang, Zhenfeng Xi. Carbodiimide-based synthesis of N-heterocycles: moving from two classical reactive sites to chemical bond breaking/forming reaction. Chem. Soc. Rev. 2020, 49, 5810. 28. Yang Wang, Qian Wang, Jieping Zhu.* Organocatalytic nucleophilic addition of hydrazones to imines: synthesis of enantioenriched vicinal diamines. Angew. Chem. Int. Ed. 2017, 56, 5612. 29. Yang Wang, Yue Chi, Wen-Xiong Zhang,* Zhenfeng Xi.* Regioselective ring expansion of 2,4-diiminoazetidines via cleavage of C–N and C(sp3)-H bonds: efficient construction of 2,3-dihydropyrimidinesulfonamides. J. Am. Chem. Soc. 2012, 134, 2926. 30. Yang Wang, Wen-Xiong Zhang,* Zitao Wang, Zhenfeng Xi.* Procedure-controlled selective synthesis of 5-acyl-2-iminothiazolines and their selenium and tellurium derivatives by convergent tandem annulation. Angew. Chem., Int. Ed. 2011, 50, 8122. 二、博士研究生招生要求 1. 具有有机合成或者药物合成等相关背景。 2. 具有一定的有机化学理论基础和实验操作技能。 欢迎有意向的同学发送个人简历、科研论文等相关材料至电子邮箱wangyang@ouc.edu.cn |
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