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ÃÀ¹ú¿µÄùµÒ¸ñ´óѧ (University of Connecticut) Changchun Liu½ÌÊÚ¿ÎÌâ×é (https://smds.engr.uconn.edu/)³ÏÕжàÃû²©Ê¿Ñо¿Éú¡£¸Ã¿ÎÌâ×鳤ÆÚÖÂÁ¦ÓÚCRISPR·Ö×ÓÕï¶Ï¼¼Êõ (CRISPR-based molecular diagnostics), ΢Á÷¿ØÕï¶ÏоƬ(microfluidic diagnostic chips), ÉúÎï´«¸Ð¼¼Êõ(biosensors), ÒÔ¼°È˹¤ÖÇÄÜ(AI)Çý¶¯µÄÁÙ´²Õï¶Ï(artificial intelligence (AI)-driven clinical diagnostics) µÈÑо¿¡£¿ÎÌâ×éµÄÑо¿ÀíÄî (research philosophy)ÊÇ¡°Interdisciplinary, Integration and Innovation (I3)¡£¸Ã¿ÎÌâ×éÓɾßÓв»Í¬Ñ§¿Æ±³¾°µÄ²©Ê¿Éú/²©Ê¿ºó×é³É£¬ÊÇÒ»¸ö¶àѧ¿Æ½»²æÈںϡ¢Ð­Í¬´´ÐµÄÑо¿ÍŶӣ¬»¶Ó­¾ßÓÐÉúÎ»¯Ñ§£¬Ò½Ñ§£¬ÉúÎ﹤³Ì£¬µç×Ó¹¤³Ì£¬»úе¹¤³ÌµÈ±³¾°µÄ±¾¿ÆÉúºÍ˶ʿÉúÉêÇë£¬ÌØ±ð»¶Ó­ÓÐÐËȤ´Óʽ»²æÑ§¿ÆÑо¿µÄͬѧ¡£

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(1) °©Ö¢ÔçÆÚÕï¶ÏºÍ²¡Ô­Ìå¼ì²â: ÒºÌå»î¼ì (liquid biopsy), ´«È¾²¡·Ö×ÓÕï¶ÏµÈ (Chong Guo et al., Science Advances, 2026, DOI: 10.1126/sciadv.aed1757; Jeong Moon et al., Nature Communications, 2025, 16, 9142. https://doi.org/10.1038/s41467-025-64205-4);

(2) CRISPRÉú»¯·ÖÎö¼¼Êõ£ºCRISPR¼¼Êõ£¬Argonaute¼¼Êõ, ºËËá(DNA, RNA)·ÖÎöºÍ¼ì²â£¬ÉúÎﻯѧ£¬·ÖÎö»¯Ñ§£¬ºÏ³ÉÉúÎïѧ(Synthetic biology)µÈ (Xiong Ding et al., Nature Communications, 2020, 11 (1), 4711, https://doi.org/10.1038/s41467-020-18575-6; Chong Guo et al., Nature Communications, 2026, 17, 194. https://doi.org/10.1038/s41467-025-66893-4);

(3) ΢Á÷¿ØÕï¶ÏϵͳºÍÈ˹¤ÖÇÄÜÇý¶¯¿ÆÑ§Ñо¿£¨AI for Science): È˹¤ÖÇÄÜ, µç×Ó¹¤³Ì£¬ÉúÎïÒÇÆ÷£¬Î¢Á÷¿ØÐ¾Æ¬¼¼Êõ£¬3D´òÓ¡¼¼ÊõµÈ(Ziyue Li, et al., Advanced Science, 2024, 11, 2310066, https://doi.org/10.1002/advs.202310066; Xin Guan et al., Advanced Science, 2026, DOI: 10.1002/advs.75149)¡£

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ÓÐÒâÏòµÄͬѧ, Ç뽫¸öÈ˼òÀú·¢Ë͵½ÒÔÏÂEmailÖ·: chaliu@uchc.edu

µ¼Ê¦¼ò½é£ºChangchun Liu is a professor in the Biomedical Engineering Department at the University of Connecticut Health Center (UConn Health). He received his Bachelor¡¯s degree in Applied Chemistry, and Master¡¯s in Organic Chemistry from Yunnan University, China. He obtained his Ph.D. in Physical Electronics at the Institute of Electronics, Chinese Academy of Sciences, China. Prior to joining UConn Health, he worked as a postdoctoral researcher and research faculty in the Department of Mechanical Engineering & Applied Mechanics, University of Pennsylvania. He has an interdisciplinary background and training spanning Engineering (i.e., biomedical, electronic, mechanical), Chemistry and Biotechnology. Dr. Liu¡¯s research interests include the development of synthetic biology, CRISPR technology, microfluidics technology, biosensors, and their biomedical applications with a focus on point-of-care molecular diagnostics of infectious diseases and cancers. He was a recipient of the NIH Career Development Award (K25), the Penn One Health Award, and the W.W. Smith Charitable Trust Research Award.

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