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yexuqing木虫之王 (文学泰斗)
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Calcium tunes snail mucus–based materials to multiple functions
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Calcium tunes snail mucus–based materials to multiple functions 钙调控蜗牛粘液基材料的多功能性 ▲ 作者：Mariella Gabler, Emeline Raguin, Ernesto Scoppola, Barbara Steigenberger, Assa Yeroslaviz, Peter Werner, et al. ▲链接： https://www.science.org/doi/10.1126/science.adx7367 ▲摘要： 众所周知，粘液是一种粘性流体；然而，蜗牛能够制造出多种粘性更高的粘液基材料，并针对不同甚至相互对立的功能（包括润滑、粘附、保护和防御）进行定制化设计。 为深入了解这种多功能性，研究组采用多学科方法，研究了蜗牛（Cepaea nemoralis）产生的五种不同粘液基材料。结果表明，蜗牛以VI型胶原蛋白作为主要结构组分，并在粘液分泌过程中添加无定形碳酸钙（ACC）。ACC在湿性粘液类型中可充当离子源，最有可能用于交联；而在干性粘液类型中，则可充当矿物前体。 这些发现揭示了这些粘弹性材料的多功能性，其能够根据钙和蛋白质含量的差异，在截然不同的状态之间实现转变。 ▲ Abstract： Mucus is known as a viscous fluid; yet, snails manufacture various mucus-based materials with much higher cohesion and tailored to different and even antagonistic functions, including lubrication, adhesion, protection, and defense. To gain insight into this versatility, we use a multidisciplinary approach to investigate five different mucus-based materials produced by the snail Cepaea nemoralis. Our results demonstrate that snails use collagen VI as a main structural component and add amorphous calcium carbonate (ACC) during mucus secretion. ACC functions as an ion source in wet mucus types, most likely for cross-linking, or as a mineral precursor in dry mucus types. These findings shed light on the versatility of these viscoelastic materials, which are able to switch between very different properties on the basis of calcium and protein content. |
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