²é¿´: 248  |  »Ø¸´: 0

ccfdhs42

гæ (³õÈëÎÄ̳)

[½»Á÷] Öйú¿ÆÑ§ÔºÉúÎïÎïÀíÑо¿Ëù·½ÏÔÑîÑо¿×é2026ÄêÕÐÆ¸ÆôÊÂ

¾ßÌ幤×÷µØµã:
Öйú¿ÆÑ§ÔºÉúÎïÎïÀíÑо¿Ëù·½ÏÔÑîÑо¿×é2026ÄêÕÐÆ¸ÆôÊÂ
н½ð:
²»´í

Öйú¿ÆÑ§ÔºÉúÎïÎïÀíÑо¿Ëù·½ÏÔÑîÑо¿×é2026ÄêÕÐÆ¸ÆôÊÂ

Òò¹¤×÷ÐèÒª£¬Öйú¿ÆÑ§ÔºÉúÎïÎïÀíÑо¿Ëù·½ÏÔÑîÑо¿×éÄâÕÐÆ¸ÌرðÑо¿ÖúÀí£¨²©Ê¿ºó£©2-4Ãû£¬ÖúÀíÑо¿Ô±/¸±Ñо¿Ô±1-2ÃûºÍ¿ÆÑÐÖúÀí2-4Ãû¡£
Ò»¡¢ PI¼ò½é
·½ÏÔÑÖйú¿ÆÑ§ÔºÉúÎïÎïÀíÑо¿ËùÑо¿Ô±£¬Ñо¿×鳤£¬²©Ê¿Éúµ¼Ê¦¡£±¾¿Æ±ÏÒµÓÚÎ人´óѧ»¯Ñ§Ñ§Ôº£¬²©Ê¿±ÏÒµÓÚÖйú¿ÆÑ§ÔºÉúÎïÎïÀíÑо¿Ëù£¬ÔÚÃÀ¹ú¹úÁ¢ÎÀÉúÑо¿Ôº(NIH)´Óʲ©Ê¿ºóÑо¿¡£2015Äê¼ÓÈëÇ廪´óѧÉúÃüѧԺÈÎÖúÀí½ÌÊÚ/¸±½ÌÊÚ¡¢²©Ê¿Éúµ¼Ê¦£¬2023Äê¼ÓÈëÖпÆÔºÉúÎïÎïÀíÑо¿ËùÈÎÑо¿Ô±¡¢²©Ê¿Éúµ¼Ê¦¡£ÏÖÈÎÖйúÉúÎïÐÅϢѧѧ»á£¨³ï£©ÉúÎï·Ö×ӽṹԤ²âÓëÄ£Äâרί»á³£ÎñίԱ¡¢ÖйúÉúÎïÎïÀíѧ»á¸ÐȾÓëÃâÒß·Ö»áÃØÊ鳤¡¢ÖйúÉúÎïÎïÀíѧ»áÉúÎï´Å¹²Õñ·Ö»áίԱ¡¢Öйú¾§Ìåѧ»áÉúÎï´ó·Ö×ÓרҵίԱ»áίԱ£¬±±¾©Àí»¯·ÖÎö²âÊÔ¼¼Êõѧ»á²¨Æ×רҵίԱ»áίԱµÈ¡£
·½ÏÔÑîÑо¿×é¾Û½¹ÓÚRNAÕûºÏ½á¹¹ÉúÎïѧÕâÒ»Ç°ÑØÁìÓò£¬ÖÂÁ¦ÓÚ¿ª·¢Ô­´´ÐÔµÄRNAÑо¿Ç°Ñؼ¼Êõ·½·¨£¬½ÒʾRNAÐÐʹ¹¦ÄܵķÖ×Ó»úÀí£¬·¢Õ¹´´ÐµÄÖÇ»ÛRNAÁÆ·¨¡£Ñо¿×éÊܹú¼Ò×ÔÈ»¿ÆÑ§»ù½ðί¡¢¿Æ¼¼²¿¡¢Öйú¿ÆÑ§Ôº¡¢±±¾©ÊÐ×ÔÈ»¿ÆÑ§»ù½ðίµÈÖØ´óÏîĿ֧³Ö£¬ÓµÓÐÀä¶³µç¾µ¡¢XÉäÏß¾§Ìåѧ¡¢ºË´Å¹²Õñ¡¢Ð¡½ÇXÉäÏßÉ¢Éä¡¢µ¥·Ö×ÓÓ«¹âµÈÊÀ½çÒ»Á÷µÄ¿ÆÑÐÆ½Ì¨£¬¿ÉΪ³ÉÔ±ÌṩÌôÕ½Ç°ÑØ¿ÆÑ§ÎÊÌâµÄ¾ø¼Ñ»·¾³¡£

¶þ¡¢ ºËÐÄÑо¿·½Ïò
1.RNA¸ßЧºÏ³ÉÓ뾫׼ÐÞÊμ¼Êõ¿ª·¢
Ñо¿×éÈںϻ¯Ñ§ÉúÎïѧÓëºÏ³ÉÉúÎïѧ¹¤¾ßÓë·½·¨£¬ÔÚǰÆÚ¹¤×÷ÖУ¬»ùÓÚNaM-TPT3·ÇÌìÈ»¼î»ùϵͳ£¬¿ª·¢ÁËһϵÁг¤Á´RNA¶¨µã±ê¼Ç½ðÄÉÃ׿ÅÁ£¡¢Ó«¹â̽ÕëÓë×ÔÐý̽ÕëµÄ¼¼Êõ£¬Ïà¹Ø¹¤×÷·¢±íÓÚPNAS 2020, Chem. Sci.2020, ACS Chem. Biol. 2022, Nat. Commun. (2021, 2023a, 2025), Int. J. Biol. Macromol. 2023, Curr. Opin. Struct. Biol. 2024, Nat. Biotechnol.2025¡£ÏÖÕýÖÂÁ¦ÓÚ¿ª·¢¸ü¸ßЧµÄRNAλµãÌØÒìÐÔÓëÇø¶ÎÑ¡ÔñÐÔ±ê¼Ç¼¼Êõ¡¢³¤Á´RNA/»·ÐÎRNAºÏ³É¼°ÕÛµþ¼¼Êõ£¬ÎªRNA½á¹¹½âÎöºÍת»¯Ó¦ÓÃÌṩȫй¤¾ß¡£
2.RNA¶¯Ì¬½á¹¹½âÎöÕûºÏ¼¼Êõ¿ª·¢
Ñо¿×éÈÚºÏÉúÎﻯѧ¡¢ÉúÎïÎïÀíѧºÍÉúÎïÐÅϢѧµÄ¶àÖÖ¹¤¾ßºÍ·½·¨£¬ÕýÖÂÁ¦ÓÚ¿ª·¢¸Éʪ½áºÏ¡¢¶àģ̬¼¼ÊõÁªÓõÄRNA¶¯Ì¬½á¹¹½âÎöÕûºÏ¼¼Êõ¡£ÓÉÓÚRNAµÄ¹ÌÓÐÈáÐԺ͸߶ȹ¹Ïó¶¯Ì¬£¬´«Í³½á¹¹½âÎö·½·¨ÓÃÓÚRNAÈýά½á¹¹½âÎö¶àÓоÖÏÞ£¬RNA¶¯Ì¬½á¹¹½âÎöؽÐ迪·¢Ð·½·¨¡£ÔÚǰÆÚ¹¤×÷ÖУ¬ÎÒÃÇ»ùÓÚµç×Ó˳´Å¹²Õñ¼¼Êõ·¢Õ¹Á˳¤Á´RNAµÄ³¤¾àÀë²â¶¨·½·¨£¬ÎÒÃǽáºÏС½ÇXÉäÏßÉ¢Éä¼¼Êõ¡¢RNAÈý¼¶½á¹¹Ô¤²âºÍ¼ÆËãÄ£Ä⣬½¨Á¢Á˽âÎö³¤Á´·Ç±àÂëRNAÒÔ¼°RNA-µ°°×Öʸ´ºÏÎïÈýά½á¹¹µÄ·½·¨¡£Ïà¹Ø¹¤×÷·¢±íÓÚCell 2013, EMBO Rep. 2019, Biophysic. J. 2022£¬Sci. China Life Sci. 2022£¬Meth. Enzymol. 2022£¬Methods Mol. Biol. 2023£¬Fundam Res. 2023£¬Nat. Commun. 2023b£¬ÎªºóÐøRNA½á¹¹½âÎöÕûºÏ¼¼ÊõµÄÓÅ»¯Éý¼¶»ýÀÛÁ˾­Ñé¡£
3.RNA¹¦ÄܵĽṹÓë¹¹Ïó¶¯Ì¬»ù´¡Ñо¿
ÎÒÃǼáÐÅ£¬Àí½âRNAµÄ¸ß¼¶½á¹¹Óë¹¹Ïó¶¯Ì¬ÊǽâËøÆäÉúÎïѧ¹¦ÄÜÓëÖÎÁÆÇ±Á¦µÄ¹Ø¼ü¡£Õë¶Ô¾ßÓнô´ÕÕÛµþµÄ¶ÌÁ´RNA£¨Í¨³£ÔÚ100 nt×óÓÒ£¬ÈçÈ˹¤ÊÊÅäÌå»òºËÌÇ¿ª¹Ø£©£¬ÎÒÃÇÀûÓÃXÉäÏß¾§Ìåѧ½âÎöÁËÆä¸ß·Ö±æÈýά½á¹¹²¢½ÒʾÁËÆä¹¦ÄܵķÖ×Ó»úÖÆ£¬Ïà¹Ø¹¤×÷·¢±íÓÚNucleic Acids Res 2023, Nat. Commun. 2024¡£Õë¶ÔÈýά½á¹¹Òѱ»½âÎöµÄ¹¦ÄÜRNA£¬ÎÒÃÇÀûÓ÷Ö×Ó¶¯Á¦Ñ§Ä£Äâ¡¢µ¥·Ö×ÓÄÉÃ׿׺͵¥·Ö×ÓÓ«¹â¹²ÕñÄÜÁ¿×ªÒƼ¼Êõ£¬¹Û²âRNA¹¹Ïó¶¯Ì¬±ä»¯Ó빲ת¼ÕÛµþ¹ý³Ì£¬Á¬½Ó¾²Ì¬½á¹¹Ó붯̬¹¦ÄÜ£¬Ïà¹Ø¹¤×÷·¢±íÓÚNat. Commun.£¨2020, 2021, 2023a, 2025£©¡£
4.ÖÇ»ÛRNAÁÆ·¨µÄÓ¦Óûù´¡Ñо¿
»ùÓÚ¶ÔRNA¸ß¼¶½á¹¹Óë¹¹Ïó¶¯Ì¬µÄÉî¿ÌÀí½â£¬ÎÒÃÇÖÂÁ¦ÓÚ¿ªÕ¹°ÐÏòRNA»ò»ùÓÚRNA£¨Èç»·ÐÎRNAºÍmRNA£©µÄÏÂÒ»´úÁÆ·¨Ñо¿£¬Íƶ¯»ù´¡Ñо¿·¢ÏÖÏòÉúÎïÒ½Ò©Ó¦ÓõÄת»¯¡£

Èý¡¢ ÕÐÆ¸¸Úλ¼°ÒªÇó
¸Úλһ£ºÌرðÑо¿ÖúÀí£¨²©Ê¿ºó£©2-4Ãû
¸ÚλְÔð£º
o¶ÀÁ¢»òÓëÍŶӳÉÔ±ºÏ×÷¿ªÕ¹Ç°ÑØ¿ÎÌâÑо¿¡£
oЭÖúÖ¸µ¼Ñо¿Éú£¬¹²Í¬ÍƽøÑо¿½ø¶È¡£
o²ÎÓë¿ÆÑлù½ðÉêÇëÓë¸ßˮƽѧÊõÂÛÎĵÄ׫д¡£
ӦƸÌõ¼þ£º
oÒÑÈ¡µÃ»ò¼´½«È¡µÃ²©Ê¿Ñ§Î»¡£
o¾ßÓÐÒÔÏÂÈÎÒ»»ò¶à¸öÑо¿±³¾°ÕßÓÅÏÈ£º
RNA»¯Ñ§ÉúÎïѧ¡¢ºÏ³ÉÉúÎïѧ¡¢Ò©Îﻯѧ¡£
RNA½á¹¹ÉúÎïѧ£¨XÉäÏß¾§Ìåѧ¡¢Àä¶³µç¾µ¡¢ºË´Å¹²Õñ¡¢Ð¡½ÇXÉäÏßÉ¢Éä¡¢ÉúÎï´ó·Ö×Ó¼ÆËãÄ£ÄâÓë½á¹¹Ô¤²â¡¢µ¥·Ö×ÓÉúÎïÎïÀí¼¼ÊõµÈ£©¡£
RNAÉúÎïѧ¡¢Î¢ÉúÎïѧÓ벡¶¾Ñ§¡£

¸Úλ¶þ£ºÖúÀíÑо¿Ô±/¸±Ñо¿Ô± 1-2Ãû
¸ÚλְÔð£º
o¶ÀÁ¢¿ªÕ¹Ñо¿£¬²¢Ð­ÖúPI¹æ»®ºÍ¹ÜÀíÑо¿·½Ïò¡£
o¸ºÔð¹Ø¼ü¼¼ÊõµÄ¹¥¹ØÓëÆ½Ì¨Î¬»¤¡£
oЭÖú¿ÎÌâ×éµÄÏîÄ¿ÉêÇë¡¢Ö´ÐÐÓë»ã±¨¡£
ӦƸÌõ¼þ£º
o¾ßÓв©Ê¿ºóÑо¿¾­Àú£¬²¢È¡µÃÍ»³öÑо¿³É¹û¡£
oÔÚÑо¿·½ÏòÉÏÓëʵÑéÊÒÓÐ¸ß¶ÈµÄÆõºÏ¶È¡£

¸ÚλÈý£º¿ÆÑÐÖúÀí 2-4Ãû
¸ÚλְÔð£º
oÔÚPIºÍ²©Ê¿ºóµÄÖ¸µ¼Ï£¬²ÎÓëÏà¹Ø¿ÎÌâµÄÑо¿¹¤×÷¡£
oЭÖú¿ÎÌâ×éµÄÏà¹Ø×éÖ¯¹ÜÀí¹¤×÷¡£
ӦƸÌõ¼þ£º
oÉúÃü¿ÆÑ§»ò»¯Ñ§»ò»ù´¡Ò½Ñ§Ïà¹Ø×¨Òµ£¬±¾¿Æ»òÒÔÉÏѧÀú¡£
oÊìÁ·ÕÆÎÕ»ùÒò¿Ë¡¡¢µ°°×ÖÊÓëRNA±í´ï´¿»¯µÈÉúÎﻯѧÓë·Ö×ÓÉúÎïѧʵÑé¼¼Êõ¡£

ËÄ¡¢ н³ê¸£ÀûÓë·¢Õ¹Ö§³Ö
ÎÒÃÇΪÄúÌṩµÄ²»Ö»ÊÇÒ»·Ý¹¤×÷£¬¸üÊÇÒ»¸öÈ«·½Î»µÄÖ°Òµ·¢Õ¹Æ½Ì¨£º
1.¾ßÓоºÕùÁ¦µÄн³ê£º¸ù¾Ý¸öÈ˾­ÀúÓë±³¾°£¬Ìṩ¼«¾ß¾ºÕùÁ¦µÄн³ê£¨¾ßÌåÃæÒ飩¡£Éç»á»ù±¾±£ÏÕ°´¹ú¼Ò×î¸ß±ê×¼Ö´ÐС£Èô³É¹¦ÉêÇë¡°²©Ð¼ƻ®¡±µÈ¹ú¼Ò»òÖпÆÔºÈ˲ÅÏîÄ¿£¬Äêн½«»ñµÃÏÔÖøÌáÉý¡£
2.Îȶ¨³É³¤µÄÖ°Òµ±£ÕÏ£ºÖúÀíÑо¿Ô±/¸±Ñо¿Ô±¸Ú룬·ûºÏÌõ¼þÕß¿ÉÄÉÈëÊÂÒµ±àÖÆ£¬½â¾ö±±¾©»§¿Ú£»³öÕ¾²©Ê¿ºó±íÏÖÓÅÐãÕߣ¬¿ÉÓÅÏÈÁôËù¹¤×÷£¨½â¾ö±±¾©»§¿Ú£©£»¿ÆÑÐÖúÀí±íÏÖÓÅÐãÕߣ¬¿ÉÍÆ¼ö½øÒ»²½ÉîÔ죨±¾¿ÆÉúÍÆ¼ö˶ʿÑо¿ÉúÏÄÁîÓª»ú»á£¬Ë¶Ê¿ÉúÍÆ¼öÆÕ²©Éú»ú»á£©¡£
3.È«ÃæµÄ¿ÆÑÐÖ§³Ö£ºÈ«Á¦Ö§³ÖÄúÉêÇë¹ú¼Ò¼°µØ·½¸÷ÀàÈ˲ÅÏîÄ¿ºÍ¿ÆÑлù½ð£»Ìṩ³ä×ãµÄ¿ÆÑо­·ÑºÍÒ»Á÷µÄʵÑéÆ½Ì¨£»¹ÄÀø²¢×ÊÖú²Î¼Ó¹úÄÚÍâ¶¥¼¶Ñ§Êõ»áÒé¡£
4.ÍêÉÆµÄÉú»î¸£Àû£ºÏíÊܹú¼Ò¹æ¶¨µÄ´øÐ½Äê¼Ù¡¢Ìå¼ìµÈÈ«·½Î»¸£Àû¡£Ñо¿ËùÌṩ²©Ê¿ºó¹«Ô¢»òס·¿²¹Ìù£¬Ð­Öú½â¾ö×ÓÅ®ÈëѧµÈÉú»îÎÊÌâ¡£

Îå¡¢ ӦƸ·½Ê½
·¢ËÍÖÁ£ºfangxy@ibp.ac.cn,gyshdghr59@yeah.net
¸öÈËÏêϸ¼òÀú¡£
ÓʼþÖ÷ÌâÇëÎñ±Ø×¢Ã÷£º¡°Ó¦Æ¸-[¸ÚλÃû³Æ]-[ÄúµÄÐÕÃû]+º£Íâ²©Ê¿Íø¡±£¨ÀýÈ磺ӦƸ-²©Ê¿ºó-ÕÅÈý+º£Íâ²©Ê¿Íø£©¡£
±¾´ÎÕÐÆ¸×Ô·¢²¼Ö®ÈÕÆð³¤ÆÚÓÐЧ£¬ÕÐÂúΪֹ¡£ÎÒÃÇÆÚ´ý¸»ÓÐÈÈÇé¡¢ÓÂÓÚ´´ÐµÄÄú¼ÓÈëÎÒÃǵÄÍŶӣ¬¹²Í¬Ì½Ë÷RNAÊÀ½çµÄ°ÂÃØ£¡
ÒÑÔÄ   »Ø¸´´ËÂ¥   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû
Ïà¹Ø°æ¿éÌø×ª ÎÒÒª¶©ÔÄÂ¥Ö÷ ccfdhs42 µÄÖ÷Ìâ¸üÐÂ
×î¾ßÈËÆøÈÈÌûÍÆ¼ö [²é¿´È«²¿] ×÷Õß »Ø/¿´ ×îºó·¢±í
[¿¼ÑÐ] ÊÛT0PÒ»ÇøSCIÎÄÕ£¬ÎÒ:8O5.51.O.54,¿ÆÄ¿ÆëÈ«,¿É£«¼± +3 9g0rmhtq5w 2026-06-27 3/150 2026-06-28 00:09 by jjz01vuwzk
[²©ºóÖ®¼Ò] ÊÛT0PÒ»ÇøSCIÎÄÕ£¬ÎÒ:8O5.51.O.54,¿ÆÄ¿ÆëÈ«,¿É£«¼± +3 9g0rmhtq5w 2026-06-27 4/200 2026-06-27 23:49 by jjz01vuwzk
[ÂÛÎÄͶ¸å] ÊÛT0PÒ»ÇøSCIÎÄÕ£¬ÎÒ:8O5.51.O.54,¿ÆÄ¿ÆëÈ«,¿É£«¼± +4 dheqf6rz6n 2026-06-27 5/250 2026-06-27 23:27 by jjz01vuwzk
[¹«Åɳö¹ú] ÊÛT0PÒ»ÇøSCIÎÄÕ£¬ÎÒ:8O5.51.O.54,¿ÆÄ¿ÆëÈ«,¿É£«¼± +3 dheqf6rz6n 2026-06-27 5/250 2026-06-27 23:04 by jjz01vuwzk
[²©ºóÖ®¼Ò] ÊÛT0PÒ»ÇøSCIÎÄÕ£¬ÎÒ:8O5.51.O.54,¿ÆÄ¿ÆëÈ«,¿É£«¼± +3 dheqf6rz6n 2026-06-27 3/150 2026-06-27 20:26 by p8adfxx4ht
[¿¼ÑÐ] ÊÛT0PÒ»ÇøSCIÎÄÕ£¬ÎÒ:8O5.51.O.54,¿ÆÄ¿ÆëÈ«,¿É£«¼± +3 7s8du2bt8y 2026-06-26 7/350 2026-06-27 18:48 by ztgu5ulw9z
[˶²©¼ÒÔ°] ÊÛT0PÒ»ÇøSCIÎÄÕ£¬ÎÒ:8O5.51.O.54,¿ÆÄ¿ÆëÈ«,¿É£«¼± +4 7s8du2bt8y 2026-06-26 8/400 2026-06-27 18:47 by ztgu5ulw9z
[¿¼²©] 27Ä격ʿÕÐÉúÐÅÏ¢ +5 rvnc 2026-06-26 8/400 2026-06-27 18:32 by rvnc
[¿¼²©] ÊÛT0PÒ»ÇøSCIÎÄÕ£¬ÎÒ:8O5.51.O.54,¿ÆÄ¿ÆëÈ«,¿É£«¼± +3 7s8du2bt8y 2026-06-26 5/250 2026-06-27 17:07 by ztgu5ulw9z
[»ù½ðÉêÇë] ÎÞÁÄ¿´¿´filecode +7 Á÷Á÷ÉË 2026-06-23 10/500 2026-06-27 16:19 by ±±¾©ÖÐÐäȽÀÏʦ
[ÂÛÎÄͶ¸å] ÇóÍÆ¼öÆÚ¿¯£¬ÖØÐ» +4 girlbaby 2026-06-23 4/200 2026-06-26 16:52 by ²»´ò¹¤Å£Âí
[˶²©¼ÒÔ°] ÓлúÄܿ緽ÏòÉ격Âð +3 ¿É¿ÉÎ÷ÀïµÄÁÖС½ 2026-06-25 3/150 2026-06-26 11:59 by ÁÖ·¼Ä¾
[ÂÛÎÄͶ¸å] Ö°³ÆÂÛÎÄͶ¸å 170+4 guoj5292 2026-06-22 12/600 2026-06-25 22:27 by Yanyanoo
[Óлú½»Á÷] ·´Ó¦ÇóÖú 10+3 slz_1986 2026-06-24 6/300 2026-06-25 21:38 by nBuï®
[ÎÄѧ·¼²ÝÔ°] ¿´¡¶¸ø°¢maµÄÇéÊé¡·ÓиР+6 myrtle 2026-06-21 10/500 2026-06-25 17:54 by myrtle
[»ù½ðÉêÇë] 2026ÄêWRÇà°Î½øÕ¹ +5 chs564851482 2026-06-24 7/350 2026-06-24 18:15 by chs564851482
[»ù½ðÉêÇë] »áÆÀʲôʱºò¿ªÊ¼£¿ +3 Vivilian 2026-06-24 4/200 2026-06-24 16:30 by jurkat.1640
[»ù½ðÉêÇë] ¹ú×ÔÈ»ÉêÇëÎåÆª´ú±í×÷´ó±ÈÆ´£¬¸Ð¾õÕâ¸öÊÇ×îÖØÒªµÄ +7 naalan7001 2026-06-22 12/600 2026-06-24 14:02 by naalan7001
[»ù½ðÉêÇë] ×Éѯ +3 _xyan818 2026-06-24 3/150 2026-06-24 08:12 by Equinoxhua
[»ù½ðÉêÇë] ÆÀίÓжàÉÙ¸ÅÂÊÖªµÀÆäËûר¼ÒÊÖÖÐÓÐÄÄЩÈ˵ı¾×Ó£¿ +6 huitong441 2026-06-22 6/300 2026-06-23 15:45 by гÇ×ÓÔø
ÐÅÏ¢Ìáʾ
ÇëÌî´¦ÀíÒâ¼û