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It has now been surprisingly discovered that the compounds of the present invention produce a marked coronary dilation of long lasting duration when administered either intravenously or per os. The 4-phenyl-1,4-dihy dropyridines of the present invention have been found to be superior to all hitherto known commercial products in duration of effectiveness and peroral effect. The action of these compounds against disturbances of the coronary blood supply is most likely favorably influenced by a nitrate effect which presumably occurs simultaneously. The following non-limitative examples illustrate the production of compounds according to the present invention. |
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2楼2009-11-16 13:54:05