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zhoudanlei

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zhoudanlei(½ð±Ò+20,VIP+0): 11-16 12:21
רҵ´Ê»ã×Ô¼ºÐ£Ò»Ï°É!

In order to implement PEG fixed-point modification of target protein and achieve stable product of modification, as well as to lay the foundation for the future fixed-point modifications of other protein medicines, the introduction of free hydrosulfide group into protein C-terminal using approach of genetic engineering, and the introduction of imino group into protein C-terminal using modification of small molecular specificity are studied.

The significance of this project is to explore the approaches of PEG fixed-point modification of two kinds of pharmaceutical protein C-terminals, to achieve resulting stable products of modification, to lay the foundation for the future fixed-point modifications of other protein medicines, and to overcome shortcomings existing in present approaches of PEG modification, e.g., poor controllability and uneven products of modification.
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