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zhoudanlei银虫 (小有名气)
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[交流]
20金币求助一段蛋白PEG 修饰的翻译
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研究采用基因工程方法在蛋白C末端引入自由巯基以及利用小分子特异性修饰在蛋白C末端引入亚胺基团的方法，实行目标蛋白的PEG定点修饰，获得稳定的修饰产物，为以后其它蛋白质药物的定点修饰奠定基础。 本项目的研究意义在于探讨两种药用蛋白质C末端的PEG定点修饰策略，获得相应的稳定性修饰产物，为以后其它蛋白质药物的定点修饰奠定基础，并克服现有的PEG修饰方法中存在的可控性差、修饰产物不均一的缺点。 |
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zhoudanlei(金币+20,VIP+0): 11-16 12:21
zhoudanlei(金币+20,VIP+0): 11-16 12:21
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专业词汇自己校一下吧! In order to implement PEG fixed-point modification of target protein and achieve stable product of modification, as well as to lay the foundation for the future fixed-point modifications of other protein medicines, the introduction of free hydrosulfide group into protein C-terminal using approach of genetic engineering, and the introduction of imino group into protein C-terminal using modification of small molecular specificity are studied. The significance of this project is to explore the approaches of PEG fixed-point modification of two kinds of pharmaceutical protein C-terminals, to achieve resulting stable products of modification, to lay the foundation for the future fixed-point modifications of other protein medicines, and to overcome shortcomings existing in present approaches of PEG modification, e.g., poor controllability and uneven products of modification. |
2楼2009-11-13 22:54:33
