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路易斯安那州立大学（LSU-Shreveport Health Center）Hongyan Guo教授招聘博士后
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postdoctoral fellow position, microbiology&immunology department, dr. hongyan guo lab, lsu-shreveport health center research direction: project 1: the role of cell death in hsv-1 pathogenesis receptor-interacting protein kinase 3 (ripk3) is a central regulator of programmed cell death, activated by upstream molecules such as ripk1, trif, and zbp1. zbp1 acts as an intracellular sensor of z-form nucleic acids and recruits ripk3 to initiate cell death. our research focuses on the zbp1 ligands that activate zbp1, elucidating the mechanisms of zbp1 activation, and determining the downstream effects of this pathway during hsv-1 infection and pathogenesis. these studies aim to define zbp1’s role as a key antiviral sensor and uncover how hsv-1 subverts host cell death pathways to facilitate infection. project 2: targeting necroptosis pathways in tumors using oncolytic hsv-1 oncolytic virotherapy is a promising cancer treatment strategy that employs viruses to selectively infect and destroy tumor cells while sparing normal tissue. hsv-1 is particularly well-suited for this approach due to its broad cellular tropism and amenability to genetic engineering. our research explores how engineered hsv-1 can be used to induce necroptosis—a form of regulated cell death—in cancer cells, thereby enhancing antitumor immune responses. by leveraging synergistic tumor models, we aim to dissect the role of necroptosis in oncolytic virus therapy and contribute to the development of safer, more effective, and highly targeted cancer treatments. mentor information： https://schoolofgradstudies.lsuh ... gy/research/guo-lab publication: https://scholar.google.com/citat ... ;amp;sortby=pubdate funding: nih r21, r01. qualifications: required: 1. ph.d. or m.d. at the time of appointment. 2. research experience in immunology, molecular biology, cancer, virology. preferred experience: 1. strong publication in related field. 2. human-derived ipsc models. 3. structural biochemistry, morphology. compensation and benefits: salary follows nih standard scale, start at $55000 for first year post-doc with extra benefits. apply: interested candidates should email the following documents to dr. hongyan guo (hongyan.guo@lsuhs.edu) with subject line as: postdoc application-name). 1. cover letter describing research experience and interests. 2. cv 3. name and contact information of three references. about lsu health shreveport (lsuhs)： lsu health shreveport (lsuhs) is a public university (r1) focused on health sciences education and located in shreveport, louisiana. microbiology and immunology: https://schoolofgradstudies.lsuh ... logy-and-immunology postdoc research: https://schoolofgradstudies.lsuh ... al-fellows/postdocs |
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